Dextran studies during acute dengue infectio

Completed

• Conditions: Dengue fever; Infections and Infestations; Dengue fever [classical dengue]

• Registration Number: ISRCTN68309519
• Lead Sponsor: niversity of Oxford (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2008-07-17
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Healthy volunteers:
1. 20 healthy Vietnamese persons aged 18 - 30 years, either sex
2. Informed consent

Patients:
1. Vietnamese adults aged 18 - 30 years , either sex
2. Admitted to Ward D at HTD with clinical dengue and evidence of vascular leakage
3. Cardiovascularly stable, not requiring intravenous (IV) fluids
4. Informed consent

Exclusion Criteria

Healthy volunteers:
1. Febrile illness within the last 3 months

Patients:
1. Medical indication for IV fluid therapy
2. Refusal to consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of dextran clearances during acute dengue infection with convalescent patterns and results from healthy controls

Secondary Outcome Measures

Name	Time	Method
Comparison of glycocalyx volume measurements during acute dengue infection with convalescent values and results from healthy controls