Comparison of propofol based total intravenous anaesthesia and desflurane in laproscopic surgeries.
- Conditions
- Health Condition 1: N979- Female infertility, unspecifiedHealth Condition 2: N739- Female pelvic inflammatory disease, unspecifiedHealth Condition 3: N839- Noninflammatory disorder of ovary,fallopian tube and broad ligament, unspecifiedHealth Condition 4: K358- Other and unspecified acute appendicitisHealth Condition 5: K37- Unspecified appendicitis
- Registration Number
- CTRI/2019/03/018251
- Lead Sponsor
- Department of Anaesthesiology and Critical Care
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Patients with ASA grade 1 and 2 and of age group 18 to 50 years with body weight 40 to 75 kg of either sex undergoing laparoscopic surgery in trendelenburg position under general anaesthesia and willing to give a written & informed consent.
1.Patients with history of previous eye disease, ophthalmic surgery, baseline IOP >21 mmHg, difference in IOP of more than 8mm Hg between two eyes, diabetic retinopathy, cataract.
2.Patients who have received medication or surgery for previously diagnosed glaucoma or taking any medication which can alter IOP.
3.Patients with major systemic disease (morbid obesity, diabetes, hypertension).
4.Major organ dysfunction â?? respiratory / cardiac / neurological.
5.Patients with gastrointestinal, hepatic, renal, mental, or psychiatric illness.
6.History of medications like hypnotics, narcotic analgesics and antihypertensive.
7.History of known allergy to anaesthetic agents used in study.
8.Anticipated difficult intubation.
9.Deaf and dumb patient.
10.Patients requiring any drug other than our anaesthesia protocol.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Intra-operative and post-operative trends in intraocular pressure changes in mm Hg at T0-T5 time points in supine position.Timepoint: T0: before anaesthesia induction. <br/ ><br>T1: 5 minute after anaesthesia induction. <br/ ><br>T2: 5 minute after establishing CO2 pneumoperitonium. <br/ ><br>T3: 20 minute after establishing CO2 pneumoperitonium in trendelenburg position. <br/ ><br>T4: 5 minute after desufflation of CO2 pneumoperitonium. <br/ ><br>T5: 5 minute after trachial extubation.
- Secondary Outcome Measures
Name Time Method (a). heart rate, systolic BP, diastolic BP and mean arterial pressure at T0-T5 time points. <br/ ><br>(b). recovery characteristics as defined by Riker sedation agitation scale(RSAS) in OR; Ramsay sedation scale(RSS) and Modified aldrete score(MAS) in PACU at arrival, 5, 10 and 15 minutes. <br/ ><br>(c). peak inspiratory pressure and EtCO2 at T1-T5 time points. <br/ ><br>(d). incidence of adverse effects if any.Timepoint: T0: before anaesthesia induction. <br/ ><br>T1: 5 minute after anaesthesia induction. <br/ ><br>T2: 5 minute after establishing CO2 pneumoperitonium. <br/ ><br>T3: 20 minute after establishing CO2 pneumoperitonium in trendelenburg position. <br/ ><br>T4: 5 minute after desufflation of CO2 pneumoperitonium. <br/ ><br>T5: 5 minute after trachial extubation.