Speech Pattern Evaluation and Analysis for Knowledge of AD
- Conditions
- Wisconsin Alzheimer's Disease Research CenterWisconsin Registry for Alzheimer's Prevention
- Registration Number
- NCT06230783
- Lead Sponsor
- University of Wisconsin, Madison
- Brief Summary
The goal of this observational study is to validate changes in speech as a measure of cognition in individuals at increased risk of Alzheimer's disease and related dementias (ADRD). This study aims to clarify how speech may be affected by Alzheimer's disease.
Participants will complete speech collection sessions and a survey at home using an iPad. Participants can expect to be in the study for 3 years.
- Detailed Description
Digital technology, including recorded speech, has the capability of providing a wealth of information about early changes to cognition and communication associated with developing Alzheimer's disease pathology, with the potential for highly accessible, yet low-burden measurement. In this project, researchers will recruit a subset of participants from two longitudinal, observational cohort studies enriched for individuals at risk for or living with Alzheimer's disease to record their speech at home with a mobile device, longitudinally. Our interdisciplinary team will then validate digital markers across all stages of Alzheimer's Disease and Related Dementias (ADRD), including the prodromal phase, and can enhance sensitivity and specificity of speech metrics while contributing valuable information about remote, noninvasive, and accessible assessment and disease monitoring.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 150
- Must be enrolled in the Wisconsin Alzheimer's Disease Research Center (W-ADRC) Clinical Core or IMPACT studies, or in the Wisconsin Registry for Alzheimer's Prevention (WRAP)
- Cognitively unimpaired or have a diagnosis of Mild Cognitive Impairment (MCI)
- Ages 40-80 years
- Completion of a W-ADRC or WRAP study visit within the past or upcoming 12 months
- Have provided W-ADRC or WRAP with blood plasma Alzheimer's Disease
- Not actively enrolled in W-ADRC or WRAP
- Diagnosis of dementia
- Impaired capacity or unwilling to consent
- Major neurological conditions
- Speech disorders
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Usability of remote at-home speech collection - objective 3 years Usability will be measured objectively through the TalkTracker mobile application by obtaining compliance metric of time to completion.
Feasibility of remote at-home speech collection 3 years Feasibility will be measured through identification of productive recruitment methods.
Usability of remote at-home speech collection - subjective 3 years Subjective measurement usability will be assessed through the System Usability Scale (SUS) given to participants after each 8-week completion period. The SUS is a 7 item questionnaire, with a range of 1 to 5 (1 = strongly disagree, 5 = strongly agree). Higher scores on questions 1, 3, 5 and 7 indicate lower usability. Higher scores on questions 2, 4 and 6 indicate higher usability.
- Secondary Outcome Measures
Name Time Method Correlations between metrics from remote at-home speech and plasma amyloid-beta (pTau-217) 3 years Correlations will be determined using mixed effects models examining change in speech measures over time with plasma amyloid-beta, covarying for age, sex and genetic risk factors
Correlation between in-clinic speech metrics and remote at-home speech metrics 3 years Correlation between in-clinic versus at-home speech samples will be measured by calculating the inter-class correlation and standard error of measurement on speech measures of interest (content information units, semantic relevance, words per minute). Determination of variance between in-person and at-home speech samples will be evaluated by analysis of covariance accounting for age, sex, education, and cognitive status.
Trial Locations
- Locations (1)
University of Wisconsin
🇺🇸Madison, Wisconsin, United States