CT based Radiomic analysis of radiation induced xerostomia in head and neck cancer radiotherapy patients
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Radiomic features such as shape based, first order, GLCM, GLRLM, GLSZM, NGDTM, GLDM
Study Overview
Brief Summary
Xerostomia is common side effect of patients with head and neck cancer who will undergo Intensity modulated radiotherapy (IMRT) due to exposure of parotid glands to radiation. It affects the quality of life (QOL) of individual. Xerostomia is graded subjectively using Radiation Therapy Oncology Group (RTOG) scoring criteria. Radiomics is currently used in diagnosis, prognosis prediction. The objective of the study is to identify the significant CT based radiomic features useful for assessing xerostomia in head and neck cancer patients treated with IMRT. The patients with head and neck cancers who had undergone radiotherapy treatment and coming for follow up at least 6 months - 1 year will be evaluated and patients with xerostomia grading from 1-4 will be referred for CT Neck. The radiomic features of parotid gland will be extracted from pre and post radiotherapy images. Wilcoxon signed‑rank test will be performed to assess the significant changes in CT radiomic features of parotid glands in post radiotherapy relative to pre radiotherapy images
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18.00 Year(s) to 70.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients with head and neck cancer treated with curative intent on follow-up of at least 6 months Clinically no evidence of recurrence disease No active treatment of cancer Non-metastatic disease at the time of follow-up.
Exclusion Criteria
- •Patients with head and neck cancer treated with curative intent on follow-up without xerostomia CT images with motion artifacts.
Outcomes
Primary Outcomes
Radiomic features such as shape based, first order, GLCM, GLRLM, GLSZM, NGDTM, GLDM
Time Frame: Radiomic features extraction and analysis - once in 4 weeks
Secondary Outcomes
No secondary outcomes reported
Investigators
Dr Saikiran P
Manipal College of Health Professions/Manipal Academy of Higher Education