tDCS and aphasia

Recruiting

Conditions: We will study participants with aphasia, an acquired language disorder caused by stroke./De participanten van het onderzoek hebben afasie, een niet-aangeboren taalstoornis die door een beroerte (CVA) is ontstaan.

Registration Number: NL-OMON27213

Lead Sponsor: Erasmus University Medical Centre. Department: rehabilitation medicine and physiotherapy

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 58

Inclusion Criteria

Aphasia after stroke
-Time post onset < 3 months
-Age 18-75 years
-Right handed
-Physical health sufficient to participate in intensive aphasia therapy

Exclusion Criteria

-Subarachnoïd Haemorrhage (SAH)
-Prior stroke resulting in aphasia
-Brain surgery in the past
-Epileptic activity in the past 12 months
-Excessive use of alcohol or drugs
-Insufficient level of Dutch premorbidly
-Premorbid (suspected) dementia
-Premorbid psychiatric disease affecting communication
-Severe non-linguistic cognitive disturbances impeding language therapy
-Pace maker
-Global aphasia (spontaneous speech 0 AND shortened Token Test < 9)
-Severe Wernicke’s aphasia (spontaneous speech 0-1 AND shortened Token Test <9)
-Residual aphasia (spontaneous speech 4-5 AND shortened Token Test > 28 AND Boston Naming Test > 150)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
language functioning i.e. word finding (Boston naming test)

Secondary Outcome Measures

Name	Time	Method
- Communication. Test: ANTAT<br>- Quality of life. Questionnaires: SAQOL, Euroqol-5D<br>- Care consumption. Questionnaires: Werk en zorg vragenlijst (Health care consumption and labour productivity)<br>- Laterality index. Measurement: fMRI<br><br>Other outcomes:<br>- demographic data (age, gender, handedness, educational level, socio-economic status)<br>- aphasia type and severity<br>- Size and location of the lesion (fMRI)<br>- Participation: CIQ<br>- overall functioning: Barthel Index<br>- adverse effects: Wong-Baker FACES Pain Rating Scale<br>