What is the clinical-effectiveness and cost-effectiveness of surgery with medial opening wedge high tibial osteotomy (HTO) compared with non-surgical treatment in the management of osteoarthritis (OA) of the knee in patients younger than 60 years?

niversity of Edinburgh0 个研究点目标入组 224 人开始时间: 2023年1月25日最近更新: 2023年10月3日

试验速览

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•1. Patient aged <60 years old with symptomatic medial compartment knee OA who the treating orthopaedic surgeon considers a suitable candidate for medial opening wedge HTO

•1. Aged <18 or >60 years old
•2. Body mass index (BMI) >40
•3. Patients considered for HTO but who DO NOT have any knee OA including:
•3.1. Offloading HTO for concomitant cartilage repair (No OA)
•3.2. Offloading HTO solely to treat ligamentous instability (ACL/PCL)
•3.3. Symptomatic avascular necrosis/osteonecrosis
•3.4. Correction of intraarticular or extraarticular post-traumatic knee deformity
•4. Patients requiring double-level knee osteotomy for correction of deformity
•5. History of inflammatory arthropathy including rheumatoid arthritis, gout, psoriasis
•6. Previous high tibial or distal femoral osteotomy in the same or contralateral knee
•7. Previous knee replacement (partial or total) in the same or contralateral knee
•8. Cognitive impairment or inability to consent.
•9. Inability to comply with study procedures.
•10. Previous history of septic arthritis in the knee

发起方

niversity of Edinburgh