Pregabalin Compared to Gabapentin for Pain Control in Lumbar Disc Surgery

Phase 3

Completed

• Conditions: Intervertebral Disc Prolapse
• Interventions: Drug: Pregabalin; Drug: Gabapentin

• Registration Number: NCT02120703
• Lead Sponsor: Aga Khan University

Brief Summary

Pregabalin is claimed to have superior analgesic effect at lower doses and better pharmacological profile as compared to gabapentin esp. in perioperative pain control after major surgeries like intervertebral disc surgery.

The investigators found that pregabalin is equivalent to gabapentin for relief of post-operative pain at a lower dose in patients undergoing intervertebral disc surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-02
• Primary Completion: 2011-10
• Study Completion: 2011-10
• Status Verified: 2014-04
• Study First Submitted: 2014-04-19
• Study First Submitted QC: 2014-04-22
• Last Update Submitted: 2014-04-22
• Study First Posted: 2014-04-23
• Last Update Posted: 2014-04-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 78

Inclusion Criteria

• 30-60 years age
• Any gender
• elective micro discectomy for intervertebral disc prolapse

Exclusion Criteria

1. micro discectomy at two or more vertebral levels,
2. Instrumentation i.e. pedicle screw fixation, hooks etc.,
3. history of steroids or alcohol use,
4. Multiple co-morbids i.e. renal failure, chronic liver disease,
5. use of anticonvulsant drugs,
6. Spinal deformity,
7. Obesity (BMI >30), 8) inability to understand and respond VAS and

9. patients with known allergy to GABA analogues.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Pregabalin	Pregabalin	-
gabapentin	Gabapentin	-

Primary Outcome Measures

Name	Time	Method
Pain	7 days	Pain measurement using Visual Analogue Score at 24 hours and 7th day of surgery

Trial Locations

Locations (1)

The Aga Khan University Hospital; 🇵🇰 Karachi, Sind, Pakistan