Investigation of neural mechanisms of COgnitive DEcline after Cardiac surgery with resting state fMRI (CODEC): a pilot study

niversity Hospitals Bristol NHS Foundation Trust0 sites20 target enrollmentAugust 8, 2018

Overview

No summary available.

Registry

who.int

Start Date

August 8, 2018

End Date

February 9, 2021

Last Updated

4 years ago

Study Type

Observational

Sex

All

Sponsor

niversity Hospitals Bristol NHS Foundation Trust

•1\. Prisoners and adults lacking capacity to consent
•2\. Contraindications to MR (implanted electronic devices, metallic foreign bodies, claustrophobia, body weight \>140 kg or waist perimeter exceeding manufacturer's recommendations and others according to manufacturer’s recommendations and generally accepted guidelines)
•3\. Patients with a neurological disorder (e.g. epilepsy, Alzheimer’s, dementia and Parkinson’s disease)
•4\. Patients with a diagnosed psychiatric disorder (e.g. schizophrenia, psychosis), drug or alcohol addiction
•5\. Patients with an already identified as having cognitive impairment (e.g. memory and/or attentional deficits) as defined by psychometric assessment or a preoperative Mini\-mental State Examination score \< 24\. The Mini\-mental State Examination will be adminstered after consent but prior to any of the cognitive assessements or fMRI scan
•6\. Patients who have previously sustained a stroke, intra\-cerebral haemorrhage, acquired brain injury
•7\. Patients unable to complete the cognitive assessments required for the trial e.g. due to language difficulties, visual or hearing impairment