Use of Prone Position Ventilation (PPV) in Danish Patients With COVID-19 Induced Severe Adult Respiratory Distress Syndrome (ARDS) Treated With Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 68
- 试验地点
- 2
- 主要终点
- 90 day mortality
研究概览
简要总结
Prone position ventilation was used 220 times in 44 out of 68 patients with severe COVID-19 induced ARDS treated with VV-ECMO. PPV treated patients did not benefit from PPV and the incidence of PPV related adverse events was high
详细描述
Purpose: To describe the use and effects of prone position ventilation (PPV) in patients with COVID-19 induced Adult Respiratory Distress Syndrome (ARDS), treated with Veno-Venous Extracorporeal membrane oxygenation (VV-ECMO).
Methods: Nationwide retrospective analysis of all COVID-19 patients in Denmark from March 2020 - December 2021with severe ARDS and need of VV-ECMO treatment. Data on the number of patients treated with PPV, number of PPV-events, timing, the time spent in prone position, physiological response types, adverse events and outcomes are reported.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 120 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with COVID-19 induced severe ARDS accepted for and treated with VV-ECMO in Denmark
排除标准
- 未提供
结局指标
主要结局
90 day mortality
时间窗: 90 days
all cause mortality 90 days after ECMO start
次要结局
- Oxygenation Response to prone position ventilation(from prone position start to prone position end)
- Time-to-wean(From start of ECMO treatment to succesful weaning from ECMO)
- Recruitment Response to prone position ventilation(from prone position start to prone position end)
研究者
Vibeke Lind Jørgensen
Consultant, PhD, principal investigator
Rigshospitalet, Denmark