Pain Prevalence After Major Craniotomy in Siriraj Hospital
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 302
- 试验地点
- 1
- 主要终点
- incidence of moderate to severe pain following major craniotomy
研究概览
简要总结
Craniotomies are generally thought to be less painful than other operations. Indeed recent studies have confirmed that pain is a common problem during the postoperative phase following craniotomy.Pain not only causes discomfort, but it is also associated with other potential adverse events such as increased sympathetic activity and elevated systemic blood pressure. These events in turn may contribute to increased intracranial pressure. Some patients may also develop chronic pain.Potent opioids have been avoided due to its potential to cause respiratory depression and risk of masking pupillary signs. As a result postoperative craniotomy pain controls are usually inadequate.
In Siriraj hospital, there are 500-600 craniotomy patients per year. Still there are no definite guidelines for postoperative pain management in these patents due to lack of information about quality of postoperative pain control after craniotomy.
Objectives
Primary objective :
- To study incidence of moderate to severe pain during first 48 hours after craniotomy.
Secondary objectives :
- To determine risk factors for moderate to severe pain during first 48 hours after craniotomy
- To evaluate side effects and complications of postoperative craniotomy pain control
- To compare patient's expectation for pain management before and after surgery
- To determine patient's satisfaction for postoperative pain management
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient undergoing major craniotomy (supratentorial surgery and Infratentorial surgery)
- •Age > 18 years
排除标准
- •Emergency or trauma
- •Need postoperative ventilatory support
- •Cannot communication
- •Psychosis
- •Not adherence to the treatment protocol
- •History of using benzodiazepine or addictive substance
结局指标
主要结局
incidence of moderate to severe pain following major craniotomy
时间窗: 48 hours
次要结局
- risk factors of moderate to severe pain following craniotomy.(48 hours)
研究者
Sirilak Suksompong
Associate Professor
Mahidol University
