The Effect of Trendelenburg Position on CCA Blood Flow

Completed

• Conditions: Perfusion; Perioperative/Postoperative Complications

• Registration Number: NCT04233177
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The investigators will evaluate the change of the common carotid artery blood flow according to patient's position and penumoperitoneum.

Detailed Description

The study will include 20 patients undergoing gynecological surgery. The common carotid artery blood flow will be measured using Doppler US during the following conditions; supine position before induction of anesthesia, supine position immediately after induction of anesthesia, supine position with penumoperitoneum, head-down position with or without pneumoperitoneum.

Study Timeline

• Study First Submitted: 2020-01-09
• Study Start: 2020-01-13
• Study First Submitted QC: 2020-01-15
• Study First Posted: 2020-01-18
• Primary Completion: 2021-02-23
• Study Completion: 2021-02-23
• Status Verified: 2022-01
• Last Update Submitted: 2022-01-17
• Last Update Posted: 2022-01-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• ASA class I,II
• patients undergoing gynecology surgery under trendelenburg position
• Age ranges from 20 to 70

Exclusion Criteria

• BMI > 32
• Pregnancy
• Patients who did not agree to study
• Patients with allergies to the drugs used in this study
• Patients with anatomical variations or lesions in cervical or cranial vascular portion
• Patients with arrhythmia that may alter patient's cardiac output(e.g. artrial fibrillation)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change of the common carotid artery blood flow velocity	1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position	Common carotid artery blood flow velocity is measured using Doppler US

Secondary Outcome Measures

Name	Time	Method
Change of the common carotid artery beat volume	1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position	Common carotid artery beat volume was calculated from median common carotid artery beat velocity and vessel diameter
Change of the common carotid artery diameter	1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position	Common carotid artery diameter is obtained using US
Change of mean arterial blood pressure	1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position	Mean arterial pressure is obtained concurrently with common carotid artery blood flow velocity measurements
Change of cardiac output	1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position	Cardiac output was obtained using FloTrac(EdwardLifescience, USA)
Change of peak inspiration airway pressure	1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position	Peak inspiratory airway pressure is obtained using the ventilator system

Trial Locations

Locations (1)

Jin-Tae Kim; 🇰🇷 Seoul, Korea, Republic of