Assessment and comparison of bone marker levels and bone density in PCOS subjects with or without Chronic Periodontitis before and after non surgical periodontal therapy - PCOS-CP

SERB DST0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•Women between 18 and 30 years of age.
•2. PCOS diagnosis will be based on the criteria by Rotterdam2 with the presence of at least two of the following: polycystic ovaries, oligomenorrhea and/or anovulation, hyperandrogenism (clinical and/or biochemical)
•3. Diagnosis of generalized moderate-to-severe chronic periodontitis will be based on presence of at least 20 teeth in the oral cavity, with at least 30% of the areas undergoing clinical attachment loss of at least 3 mm and a probing depth of >=5 mm and radiographic evidence of bone loss3.
•4. The systemically healthy group will be based on; history of regular menstrual cycles, no clinical or biochemical sign of hyperandrogenism, matching with the PCOS group in body mass index (BMI) and exclusion of PCOS by ultrasound examination.
•5. Willingness to sign consent for study including participation with collection of blood specimens
•6. Willingness to discontinue OCP for duration of study period up to 18 weeks

•2. History of smoking or any drug usage, including oral contraceptives, systemic antibiotics (during the previous 6 months) or continuous use of NSAIDs
•3. History of any dental treatment in the previous six months.

发起方

SERB DST