Resistance Exercise Versus Aerobic Exercise Combined With Metformin Therapy in the Treatment of Type 2 Diabetes: A 12-Week Comparative Clinical Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Type 2 Diabetes
- Sponsor
- Prince Sattam Bin Abdulaziz University
- Enrollment
- 57
- Locations
- 1
- Primary Endpoint
- Change in Glycated hemoglobin% (HbA1c%)
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Background: Both exercise and metformin are used to control blood glucose levels in patients with type 2 diabetes mellitus (T2DM), while no previous studies have investigated the effect of resistance exercise combined with metformin versus aerobic exercise with metformin in T2DM patients. This study was conducted to compare the effects of resistance exercise combined with metformin versus aerobic exercise with metformin in T2DM patients.
Detailed Description
Background: Both exercise and metformin are used to control blood glucose levels in patients with type 2 diabetes mellitus (T2DM), while no previous studies have investigated the effect of resistance exercise combined with metformin versus aerobic exercise with metformin in T2DM patients. This study was conducted to compare the effects of resistance exercise combined with metformin versus aerobic exercise with metformin in T2DM patients. Methods: A total of fifty-seven T2DM patients with a mean age of 46.2±8.3 years were randomized to three study groups; each group included nineteen patients. The first group conducted a resistance exercise program (REP, 50-60% of 1RM, for 40-50 min) combined with metformin, the second group conducted an aerobic exercise program (AEP, 50-70% maxHR, for 40-50 min) combined with metformin, and the third group received only metformin without exercise intervention (Met group). The study program was conducted thrice weekly for consecutive twelve weeks. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), homeostatic model assessment of insulin resistance (HOMA-IR), and maximal oxygen uptake (VO2max) were evaluated before and after study intervention.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of T2DM
- •Glycated hemoglobin (HbA1c) ≥8.0%
- •A previous inactive lifestyle
- •Not receiving insulin or diabetic medications except for metformin
- •Metformin dosage of 1000-1500 mg daily.
Exclusion Criteria
- •Pregnancy
- •Corticosteroid medications
- •Uncontrolled systemic diseases
- •Any physical limits that affect exercise training
Outcomes
Primary Outcomes
Change in Glycated hemoglobin% (HbA1c%)
Time Frame: Pre and post 12-week intervention
It was were evaluated before and after study intervention by collecting blood samples after fasting 10-12 hours overnight.
Secondary Outcomes
- Fasting blood glucose (FBG)(Pre and post 12-week intervention)
- homeostatic model assessment of insulin resistance (HOMA-IR)(Pre and post 12-week intervention)
- The maximum oxygen uptake (VO2max)(Pre and post 12-week intervention)