Resistance Exercise Versus Aerobic Exercise Combined With Metformin Therapy in the Treatment of Type 2 Diabetes: A 12-Week Comparative Clinical Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 57
- 试验地点
- 2
- 主要终点
- Change in Glycated hemoglobin% (HbA1c%)
研究概览
简要总结
Background: Both exercise and metformin are used to control blood glucose levels in patients with type 2 diabetes mellitus (T2DM), while no previous studies have investigated the effect of resistance exercise combined with metformin versus aerobic exercise with metformin in T2DM patients. This study was conducted to compare the effects of resistance exercise combined with metformin versus aerobic exercise with metformin in T2DM patients.
详细描述
Background: Both exercise and metformin are used to control blood glucose levels in patients with type 2 diabetes mellitus (T2DM), while no previous studies have investigated the effect of resistance exercise combined with metformin versus aerobic exercise with metformin in T2DM patients. This study was conducted to compare the effects of resistance exercise combined with metformin versus aerobic exercise with metformin in T2DM patients.
Methods: A total of fifty-seven T2DM patients with a mean age of 46.2±8.3 years were randomized to three study groups; each group included nineteen patients. The first group conducted a resistance exercise program (REP, 50-60% of 1RM, for 40-50 min) combined with metformin, the second group conducted an aerobic exercise program (AEP, 50-70% maxHR, for 40-50 min) combined with metformin, and the third group received only metformin without exercise intervention (Met group). The study program was conducted thrice weekly for consecutive twelve weeks. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), homeostatic model assessment of insulin resistance (HOMA-IR), and maximal oxygen uptake (VO2max) were evaluated before and after study intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 35 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of T2DM
- •Glycated hemoglobin (HbA1c) ≥8.0%
- •A previous inactive lifestyle
- •Not receiving insulin or diabetic medications except for metformin
- •Metformin dosage of 1000-1500 mg daily.
排除标准
- •Pregnancy
- •Corticosteroid medications
- •Uncontrolled systemic diseases
- •Any physical limits that affect exercise training
结局指标
主要结局
Change in Glycated hemoglobin% (HbA1c%)
时间窗: Pre and post 12-week intervention
It was were evaluated before and after study intervention by collecting blood samples after fasting 10-12 hours overnight.
次要结局
- Fasting blood glucose (FBG)(Pre and post 12-week intervention)
- homeostatic model assessment of insulin resistance (HOMA-IR)(Pre and post 12-week intervention)
- The maximum oxygen uptake (VO2max)(Pre and post 12-week intervention)