Effects of Arginine Supplementation associated with an Exercise Training Program in Chronic Obstructive Pulmonary Disease

Not Applicable

• Conditions: Chronic Obstructive Pulmonary Disease, Unspecified / Chronic Obstructive Pulmonary Disease

• Registration Number: RBR-8rkwnw
• Lead Sponsor: niversidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-01-22
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Patients with moderate to very severe chronic obstructive pulmonary disease; with age equal to or greater than 40 years; of both sexes.

Exclusion Criteria

Current smoking; presence of associated diseases that make it impossible to carry out any of the study evaluations or limit the progression of training such as osteoarthritis, severe cardiovascular and neurological conditions and non-signing of the informed consent form.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in endothelial function assessed by brachial artery flow-mediated dilation by means of brachial artery ultrasound performed at the beginning and end of each cross-over series of supplementation and before and after 24 sessions of pulmonary rehabilitation.;Change in endothelial function assessed by the index of reactive hyperemia by means of peripheral arterial tonometry performed at the beginning and at the end of each cross-over series of supplementation and before and after 24 sessions of pulmonary rehabilitation.