Craniopharyngioma With Tumoral Hemorrhage

Completed

• Conditions: Apoplexy; Craniopharyngioma
• Interventions: Other: intratumoral hemorrhage

• Registration Number: NCT04937335
• Lead Sponsor: Tongji Hospital

Brief Summary

Clinical data of 185 consecutive patients receiving resective operation with a pathological diagnosis of craniopharyngioma in our hospital between January 2013 and February 2021 were collected. Among these patients, 18 of them were recognized as craniopharyngioma with tumoral hemorrhage during the operation.

Detailed Description

For each case, age, gender, smoking status, alcohol intake, past history, symptoms, blood pressure, blood cell count, blood biochemical tests, coagulation tests, hormone tests, radiological results, surgical treatment and the outcome at discharge were collected. The first test result after admission and before the operation was taken for the items of blood tests with multiple times in the analysis.

Study Timeline

• Study Start: 2013-01-01
• Primary Completion: 2021-02-01
• Study Completion: 2021-02-01
• Status Verified: 2021-06
• Study First Submitted: 2021-06-07
• Study First Submitted QC: 2021-06-21
• Last Update Submitted: 2021-06-21
• Study First Posted: 2021-06-24
• Last Update Posted: 2021-06-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 185

Inclusion Criteria

• receive resective operation with a pathological diagnosis of craniopharyngioma in our hospital
• enter our hospital between January 2013 and February 2021

Exclusion Criteria

• have a non-craniopharyngioma or unverified pathological diagnosis at discharge
• have received surgical or radiological treatment on the sellar region
• receive treatment of coagulation modulation, immunosuppressive agents or chemotherapeutic drugs
• combine with other clinical emergencies including acute myocardial infarction, cerebral stroke, trauma and sepsis at admission
• have been diagnosed with other tumors, hematological diseases, autoimmune diseases, liver failure or renal failure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Hemorrhage group	intratumoral hemorrhage	Patients recognized as craniopharyngioma pathologically with tumoral hemorrhage observed during the operation

Primary Outcome Measures

Name	Time	Method
craniopharyngioma with tumoral hemorrhage	during the operation	Current study is a case-control study whose primary outcome is tumoral hemorrhage observed during the operation, which devided the craniopharyngioma patients into hemorrhage group and non-hemorrhage group.