Study of Rotatory Vestibular Tests in Major Depression Patients and Healthy Control Subjects.

Completed

• Conditions: Depression; Vestibular Disorder

• Registration Number: NCT03421847
• Lead Sponsor: Vest Brain,Centro de Estudios Neurovestibulares

Brief Summary

This study evaluates the vestibular activity in major depression patients and healthy controls using the rotatory test and electronystagmography.

Detailed Description

Previous studies showed abnormal vestibular activity in major depression patients using caloric vestibular tests. The present study investigates the vestibular response to vestibular rotatory tests in major depression subjects and healthy controls.

Study Timeline

• Study Start: 2005-07-01
• Primary Completion: 2006-12-15
• Study Completion: 2006-12-15
• Study First Submitted: 2018-01-29
• Study First Submitted QC: 2018-01-29
• Status Verified: 2018-02
• Last Update Submitted: 2018-02-02
• Study First Posted: 2018-02-05
• Last Update Posted: 2018-02-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

• male and females adults (18 years or older)
• met the Diagnosing and Statistical Manual of Mental Disorders (DSM-IV-R, American Psychiatric Association, 2000) criterion.
• had a score of 12 or more in the Hamilton Rating Scale, 21 items for Depression.
• with or without actual pharmacological treatment, except benzodiazepines that were suspended 24 hours before the rotary test when corresponding.

Exclusion Criteria

• pregnant women
• neurologic disorders.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Vestibular Activity	Vestibular rotatory test for each participant is about 50- 60 minutes. One rotatory test per participant.	The primary outcome corresponds to the vestibular activity. The vestibular stimulation provided by the rotatory chair is sensed by the inner ear´s vestibular receptors and generates reflex ocular movements(Vestibulo Ocular Reflex) registrated by electronystagmography. The main outcome corresponds to the asymmetry of the vestibular activity between both ears.