Effect of Controlled Ovarian Stimulation in Quality of Oocyte and Embryo

Phase 2

• Conditions: Ovarian Stimulation
• Interventions: Drug: HHMG

• Registration Number: NCT04539067
• Lead Sponsor: Minia University

Brief Summary

Investigate and compare the efficacy of H FSH plus HMG Vs HMG alone on oocyte and embryo quality in IcsI patients

Detailed Description

70 patients divided in to 2groups Group A controlled ovarian stimulation with H FSH and HHMg Group B controlled ovarian stimulation with HMG alone Results will be discussed later

Study Timeline

• Status Verified: 2020-08
• Study First Submitted: 2020-08-25
• Study First Submitted QC: 2020-08-31
• Last Update Submitted: 2020-08-31
• Study Start: 2020-09-01
• Study First Posted: 2020-09-04
• Last Update Posted: 2020-09-04
• Primary Completion: 2021-09
• Study Completion: 2021-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 70

Inclusion Criteria

1. Infertil women aged from 20_35yr
2. Normal utreus
3. Normal ovaries
4. unexplained infertility
5. no endometriosis

Exclusion Criteria

1 - poor responders to gonadotropin 2-Prior history of more than 3unsucceful ICSI 3-Any malformation of sexual organs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
HMG group	HHMG	Induction of ovulation from 2nd day of cycle Follow diameter of follicle When follicle 18:22mm Receive HMG
H FSH plus HHMG	HHMG	Follow up ovulation from the 2nd day to 5th of menstruation cycle When follicle diameter 18mm to 22mm made induction of ovulation

Primary Outcome Measures

Name	Time	Method
Comparison between the efficacy of controlled ovarian stimulation with H FSH plus HMG Vs HmG alone on oocyte and embryo quality in IcsI patients	9 months	Comparison between the efficacy of controlled ovarian stimulation with H FSH plus HMG Vs HmG alone on oocyte and embryo quality in IcsI patients