Effect of Gabapentin on Idiopathic Subjective Tinnitus
- Registration Number
- NCT00555776
- Lead Sponsor
- Islamic Azad University of Mashhad
- Brief Summary
The purpose of this study is to determine wether Gabapentin which is useful for treating neuropathic pains, is effective on idiopathic subjective tinnitus.
- Detailed Description
Tinnitus is the perception of sound in the absence of acoustic stimulation. It can be subjective or objective. .
Despite numerous researches,no effective treatment for people who suffer from tinnitus has yet been stablished.
As there are many evidences suggesting that loss of inhibition in the central nervous system may be responsible for many aspects of auditory dysfunction,including tinnitus; and as Gabapentin (Neurontin), a gama-aminobutyric acid (GABA) analogue, is an effective medication in conditions where inhibition in the CNS is impaired; we guess that Gabapentin might be useful for treating idiopathic subjective tinnitus.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 70
- patients with subjective idiopathic tinnitus
- tinnitus with known underlying cause
- pregnant women and patients younger than 18 or older than 75 years
- patients with impaired renal function
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 2 placebo Randomly,half of the subjects receive placebo. 1 Gabapentin Randomly,half of the subjects are given Gabapentin.
- Primary Outcome Measures
Name Time Method Reduction in the sensation of Tinnitus by the patient or complete resolution of tinnitus;by the patient's scoring it from one to ten, before and after prescribing Gabapentin. two months
- Secondary Outcome Measures
Name Time Method Relieve of complications of tinnitus, such as sleep difficulties. two months
Trial Locations
- Locations (1)
ENT department of Mashhad Azad medical university
🇮🇷Mashhad, Khorasan razavi, Iran, Islamic Republic of