Prospective Case-Only Study of Neuromuscular Pathology in Patients on Mechanical Ventilation in the Neurosurgical Intensive Care Unit
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 135
- 试验地点
- 1
- 主要终点
- incidence of critical illness neuromuscular abnormalities (CINMAs)
研究概览
简要总结
The aim of this research is to investigate critical illness neuromuscular abnormalities in neurocritical care patients.
详细描述
Since 1984, the problem of critical illness neuromuscular abnormalities (CINMAs) has attracted considerable interest. According to these studies, CINMAs include the muscular weakness that accompanies critical illness resulting from polyneuropathy and/or myopathy and can be seen in 25-85% of cases of critically ill patients. Clinically, CINMAs present as symmetric flaccid tetraparesis and difficulty weaning off mechanical lung ventilation. However, these data are derived from treating non-specialized intensive care unit (ICU) patients. In this research, we wished to investigate CINMAs in neurocritical care patients. From day one of the patients' participation in the research and until a discharge from the ICU (or death), daily neurological surveys and weekly nerve conduction studies were performed. Based on the results of each nerve conduction study, an index of neuromuscular damage was noted to evaluate the severity of the CINMAs. Needle electromyography and muscle biopsy were not used
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age: 16 years and older
- •Acute primary cerebral pathology
- •Mechanical ventilation
- •Signs of systemic inflammatory response
- •Exclusion of the possibility of an initial pathology of the spinal cord, peripheral nervous system and muscles in past medical history
排除标准
- •Brain stem or bilateral hemispheric lesions with tetraparesis at the onset of illness
- •Inability to perform high-grade nerve conduction studies
结局指标
主要结局
incidence of critical illness neuromuscular abnormalities (CINMAs)
时间窗: within the first week of mechanical ventilation
次要结局
- clinical and neurophysiological characteristics of CINMAs(within the first week of mechanical ventilation)
- influence оf phrenic nerve pathology on weaning from mechanical ventilation(during weaning period)
- dynamics of the neurophysiological characteristics of CINMAs(during stay in ICU)