Critical Illness Neuromuscular Abnormalities in Neurocritical Care Patients

Completed

• Conditions: Muscle Weakness; Critical Illness

• Registration Number: NCT00893633
• Lead Sponsor: Clinical Institute of the Brain, Russia

Brief Summary

The aim of this research is to investigate critical illness neuromuscular abnormalities in neurocritical care patients.

Detailed Description

Since 1984, the problem of critical illness neuromuscular abnormalities (CINMAs) has attracted considerable interest. According to these studies, CINMAs include the muscular weakness that accompanies critical illness resulting from polyneuropathy and/or myopathy and can be seen in 25-85% of cases of critically ill patients. Clinically, CINMAs present as symmetric flaccid tetraparesis and difficulty weaning off mechanical lung ventilation. However, these data are derived from treating non-specialized intensive care unit (ICU) patients. In this research, we wished to investigate CINMAs in neurocritical care patients. From day one of the patients' participation in the research and until a discharge from the ICU (or death), daily neurological surveys and weekly nerve conduction studies were performed. Based on the results of each nerve conduction study, an index of neuromuscular damage was noted to evaluate the severity of the CINMAs. Needle electromyography and muscle biopsy were not used

Study Timeline

• Study Start: 2004-03
• Primary Completion: 2007-01
• Study Completion: 2007-01
• Study First Submitted: 2009-05-05
• Study First Submitted QC: 2009-05-05
• Study First Posted: 2009-05-06
• Status Verified: 2009-07
• Last Update Submitted: 2009-07-09
• Last Update Posted: 2009-07-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 135

Inclusion Criteria

• Age: 16 years and older
• Acute primary cerebral pathology
• Mechanical ventilation
• Signs of systemic inflammatory response
• Exclusion of the possibility of an initial pathology of the spinal cord, peripheral nervous system and muscles in past medical history

Exclusion Criteria

• Brain stem or bilateral hemispheric lesions with tetraparesis at the onset of illness
• Inability to perform high-grade nerve conduction studies

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
incidence of critical illness neuromuscular abnormalities (CINMAs)	within the first week of mechanical ventilation

Secondary Outcome Measures

Name	Time	Method
clinical and neurophysiological characteristics of CINMAs	within the first week of mechanical ventilation
influence оf phrenic nerve pathology on weaning from mechanical ventilation	during weaning period
dynamics of the neurophysiological characteristics of CINMAs	during stay in ICU

Trial Locations

Locations (1)

Clinical Institute of the Brain; 🇷🇺 Ekaterinburg, Russian Federation