Bone diseases among children exposed to steroids as part of their treatment
- Conditions
- Health Condition 1: C910- Acute lymphoblastic leukemia [ALL]Health Condition 2: N040- Nephrotic syndrome with minor glomerular abnormalityHealth Condition 3: M084- Pauciarticular juvenile rheumatoidarthritisHealth Condition 4: M321- Systemic lupus erythematosus withorgan or system involvement
- Registration Number
- CTRI/2023/08/055954
- Lead Sponsor
- Department of Health Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Children with the following three diseases, who are either newly diagnosed or on follow up will be recruited:
1.Rheumatic Disease (RD):
Children between 1 month to 18 years with diagnosis of Juvenile Idiopathic Arthritis (JIA), Systemic Lupus Erythematosus (SLE). (13)(14).
2.Nephrotic syndrome (NS):
Children between 1 month to 18 years with diagnosis of Nephrotic syndrome (first episode, relapse, steroid dependent, steroid resistant). (15).
3.Acute Lymphoblastic leukemia (ALL):
Children between 1 month to 18 years with diagnosis of Acute Lymphoblastic Leukemia (16).
Newly diagnosed cases of all three diseases will be included within 14 days of diagnosis. The follow up cases will be included if they have received at least 3 months of daily or alternate day steroid therapy, more than physiological replacement dose ( >2 mg/m2/day prednisolone equivalent) in last 6 months.
Not provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Incidence of VF & GIO among children exposed to steroidsTimepoint: At enrolment, 6 and 12 months after enrollment <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1.To study the risk factors for development of VF & osteoporosis <br/ ><br>2.To study the progression of VF and osteoporosis among those with VF at the time of diagnosis <br/ ><br>3.Correlation of lumbar spine BMD with vertebral fragility fracture <br/ ><br>Timepoint: At recruitement, 6 months & 1 year after recruitement