A Prospective Study To Evaluate The Role Of Acute Phase Reactants In The Management Of Odontogenic Space Infections
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Patient’s CBC, ESR, CRP and serum procalcitonin levels will be evaluated on 1st day followed by incision and drainage and /or extraction of offending tooth. Patient’s post operative levels of CBC, ESR, CRP and serum procalcitonin will be evaluated on the 5th day after intervention
研究概览
简要总结
Maxillofacial infections are life-threatening diseases commonly caused by odontogenic origin. Facial space infections of odontogenic origin have latent spaces that are anatomically connected to each other, thus allowing the infections to spread which can progress to sepsis. Acute phase reactants (APR) are inflammation markers that exhibit significant changes Maxillofacial in serum concentration during inflammation. CRP (C-Reactive protein), ESR (Erythrocyte Sedimentation Rate, TLC (Total Leucocyte Count )and serum procalcitonin are important mediators reduced in the liver during acute and chronic inflammatory states. This purpose of this study is to evaluate the values of acute phase reactants such as Erythrocyte Sedimentation Rate (ESR), TLC ,CRP (C-Reactive protein) and serum procalcitonin in patients having odontogenic space infections both preoperatively and postoperatively .
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 19.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •Male or female patients, aged 19 years or older with fascial space infection of odontogenic origin.
- •Any carious/ periodontally compromised teeth which can be considered as foci of infection.
- •Patients falling in ASA class 1, 2 and
- •Patients willing for procedure and subsequent follow ups.
排除标准
- •Patients falling in ASA class 4 and
- •Patents who are on oral / I.V antibiotic therapy prior to blood investigations.
- •Patients on long term steroids.
- •Patients who are pregnant.
- •Patients with facial space infection of non odontogenic origin.
- •Patients previously radiated maxillofacial region.
- •Patents who are not willing to give consent.
结局指标
主要结局
Patient’s CBC, ESR, CRP and serum procalcitonin levels will be evaluated on 1st day followed by incision and drainage and /or extraction of offending tooth. Patient’s post operative levels of CBC, ESR, CRP and serum procalcitonin will be evaluated on the 5th day after intervention
时间窗: 1st day , 5th day
次要结局
- other postoperative parameters include 1.) Maximum mouth opening.2.) Swelling 3.) Pain(patient will be followed up on first, third, fifth, seventh and tenth post-operative day)
研究者
Dr Nitin Verma
Punjab Government Dental College and Hospital, Amritsar