What is Sleep's Role in Alzheimer's Disease? Insight From Healthy Aging
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sleep
- Sponsor
- University of Massachusetts, Amherst
- Enrollment
- 584
- Locations
- 1
- Primary Endpoint
- Change in memory accuracy for intervention compared to control
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The specific objective of this proposed research is to understand whether deficits in sleep-dependent memory changes reflect age-related changes in sleep, memory, or both. The central hypothesis is that changes in both memory and sleep contribute to age-related changes in sleep-dependent memory processing. To this end, the investigators will investigate changes in learning following intervals of sleep (overnight and nap) and wake in young and older adults.
Detailed Description
Exp 1: Using neuroimaging, the investigators will consider whether differences in brain areas engaged during memory encoding contribute to age-related changes in sleep-dependent memory consolidation for a word-pair learning task. Exp 2: The investigators will examine the rate of memory decay between encoding and sleep using two probes of declarative memory (word-pair learning and visuo-spatial learning). Exp 3: The investigators will provide additional opportunity for encoding of the word-pair and visuo-spatial learning tasks. Exp 4: Using neuroimaging, the investigators will examine neural engagement during encoding and performance following intervals of sleep and wake. Exp 5: The investigators will examine the rate of decay of motor sequence learning. Exp 6: The investigators will examine whether enhanced training ('overtraining') improves sleep-dependent memory consolidation for older adults.
Investigators
Rebecca Spencer
Professor
University of Massachusetts, Amherst
Eligibility Criteria
Inclusion Criteria
- •Age 18-80 yrs
- •Healthy sleeper
- •No diagnosed sleep or neurodegenerative disorder
Exclusion Criteria
- •Past diagnosis of any sleep disorder or evidence of a sleep disorder as assessed by self-reported sleep quality assessments, a standardized diagnostic interview, and an acclimation night of polysomnography. Using acclimation-night polysomnography, participants will be excluded with an Apnea-Hypopnea Index \>15; a Period-Limb Movement in Sleep index of \>15/hr; sleep-onset latency \> 45 min (indicative of insomnia); or sleep efficiency \< 80% (see Edinger et al., Sleep, 2004). In cases in which questions arise regarding a participants' inclusion or sleep records, a practicing neurologist board-certified in sleep medicine will review the documentation.
- •Past diagnosis neurological illness or head injury
- •Reported average sleep per night \< 5 or \> 9 hrs
- •Current employment involving shift work or an inability to keep a regular sleep schedule during the week prior to testing
- •Current use of psychotropic, recreational drugs, or sleep-altering medications (sleep medications, cold medicines within the past week, clonidine, sympathomimetic stimulants)
- •Daily caffeine intake of \> 4 cups (coffee, tea, colas)
- •Weekly alcohol intake of \> 10 cups
- •Pregnancy or \< 12 months post-partum
- •History of bipolar disorder, mania, or current evidence of depression as measured by Beck Depression Inventory score \> 25
- •Abnormal sleep (e.g., shift work, travel across \>2 time zones within the past 3 months).
Outcomes
Primary Outcomes
Change in memory accuracy for intervention compared to control
Time Frame: 2 hours (Experiments 1,4) or 12 hours (Experiments 2,3,5,6)
We will measure memory accuracy before the sleep/wake interval and subtract this from memory accuracy after the sleep wake interval. If sleep benefits memory then this value will be greater in the sleep condition compared to the wake condition.