What is Sleep's Role in Alzheimer's Disease? Insight From Healthy Aging
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 584
- 试验地点
- 2
- 主要终点
- Change in memory accuracy for intervention compared to control
研究概览
简要总结
The specific objective of this proposed research is to understand whether deficits in sleep-dependent memory changes reflect age-related changes in sleep, memory, or both. The central hypothesis is that changes in both memory and sleep contribute to age-related changes in sleep-dependent memory processing. To this end, the investigators will investigate changes in learning following intervals of sleep (overnight and nap) and wake in young and older adults.
详细描述
Exp 1: Using neuroimaging, the investigators will consider whether differences in brain areas engaged during memory encoding contribute to age-related changes in sleep-dependent memory consolidation for a word-pair learning task.
Exp 2: The investigators will examine the rate of memory decay between encoding and sleep using two probes of declarative memory (word-pair learning and visuo-spatial learning).
Exp 3: The investigators will provide additional opportunity for encoding of the word-pair and visuo-spatial learning tasks.
Exp 4: Using neuroimaging, the investigators will examine neural engagement during encoding and performance following intervals of sleep and wake.
Exp 5: The investigators will examine the rate of decay of motor sequence learning.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-80 yrs
- •Healthy sleeper
- •No diagnosed sleep or neurodegenerative disorder
排除标准
- •Past diagnosis of any sleep disorder or evidence of a sleep disorder as assessed by self-reported sleep quality assessments, a standardized diagnostic interview, and an acclimation night of polysomnography. Using acclimation-night polysomnography, participants will be excluded with an Apnea-Hypopnea Index >15; a Period-Limb Movement in Sleep index of >15/hr; sleep-onset latency > 45 min (indicative of insomnia); or sleep efficiency < 80% (see Edinger et al., Sleep, 2004). In cases in which questions arise regarding a participants' inclusion or sleep records, a practicing neurologist board-certified in sleep medicine will review the documentation.
- •Past diagnosis neurological illness or head injury
- •Reported average sleep per night < 5 or > 9 hrs
- •Current employment involving shift work or an inability to keep a regular sleep schedule during the week prior to testing
- •Current use of psychotropic, recreational drugs, or sleep-altering medications (sleep medications, cold medicines within the past week, clonidine, sympathomimetic stimulants)
- •Daily caffeine intake of > 4 cups (coffee, tea, colas)
- •Weekly alcohol intake of > 10 cups
- •Pregnancy or < 12 months post-partum
- •History of bipolar disorder, mania, or current evidence of depression as measured by Beck Depression Inventory score > 25
- •Abnormal sleep (e.g., shift work, travel across >2 time zones within the past 3 months).
- •Diagnosis of any Axis I disorder, neurological illness or head injury (according to Demographic and Health History form);
- •Score indicative of cognitive dysfunction (subtest scores < 40)
- •Beck Depression Scale score indicative of depression (> 19).
- •Additionally, individuals will be excluded from magnetic resonance imaging studies (Exps 1, 4) for:
- •Left handed or ambidextrous
- •Claustrophobia
- •Presence of metal (thoroughly screened via questionnaire and metal detector)
结局指标
主要结局
Change in memory accuracy for intervention compared to control
时间窗: 2 hours (Experiments 1,4) or 12 hours (Experiments 2,3,5,6)
We will measure memory accuracy before the sleep/wake interval and subtract this from memory accuracy after the sleep wake interval. If sleep benefits memory then this value will be greater in the sleep condition compared to the wake condition.
次要结局
未报告次要终点
研究者
Rebecca Spencer
Professor
University of Massachusetts, Amherst