NL-OMON22916招募中不适用
Towards Response guided ADAptive Radiotherapy for organ preserving treatment of intermediate risk rectal cancer: a phase I dose finding trial
MC Utrecht0 个研究点目标入组 45 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 45
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •- Biopsy proven rectal adenocarcinoma;
- •- Intermediate risk tumor, based on TNM (AJCC 8th edition) stage (T3c-d (MRF-) N0M0 or cT1-3 (MRF-) N1M0)
- •- Mid-rectal or distal rectal tumor: lower border anteriorly not above peritoneal fold, upper border below sigmoid take-off;
- •- Indication for neoadjuvant short course radiotherapy as judged by multidisciplinary tumor board discussion;
- •- Fit for multimodal treatment, as judged by multidisciplinary tumor board discussion;
- •- Written informed consent.
排除标准
- •- Mucinous tumor or neuro-endocrine tumor, as defined on MRI and/or histopathology;
- •- No residual luminal tumor after local excision;
- •- Recurrent tumor or regrowth after previous treatment;
- •- Extra-mesorectal pathological lymph nodes;
- •- Planned systemic therapy (either with curative or palliative intent);
- •- History of inflammatory bowel disease;
- •- Prior pelvic radiotherapy;
- •- Contraindications for MRI at 1.5T;
- •- Orthopedic hip implants;
- •- Pregnancy.
研究者
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