Rehabilitating Visual Deficits Caused by Stroke: Neurochemical and Neurophysiological Markers for Optimal Recovery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hemianopia
- Sponsor
- University of Oxford
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Change in motion discrimination thresholds after 6 months of training
- Status
- Recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
This research aims to understand the efficacy of a visual training task to improve visual loss after stroke, also known as hemianopia. The investigators aim to understand whether training can improve vision and which areas or pathways in the brain are responsible for this improvement.
Detailed Description
Damage to the primary visual cortex (V1) due to stroke usually results in loss of visual function in half of the visual world, this is known as hemianopia. This visual loss can negatively affect quality of life, as most stroke survivors are no longer permitted to drive and have difficulties with navigation and socialising. There are currently limited treatment options, although recent evidence suggests that visual training can be effective in improving visual function (Huxlin et al, 2009; Cavanaugh \& Huxlin, 2017). The aim of this research is to determine the capacity for visual rehabilitation after stroke using visual training and to understand the underlying brain mechanisms that might drive these improvements. This study will help the investigators to understand the brain mechanisms involved in visual rehabilitation and may allow the investigators to predict those most likely to benefit from visual rehabilitation in the future. Twenty stroke survivors with hemi- or quadrantanopia will complete a 6-month visual motion discrimination training programme at home. Each participant will have three study visits; at baseline, 6-months and 9-months. At each visit the investigators will take measures of 1) visual fields 2) detailed tests of visual function 3) quality of life and 4) MRI scans of brain structure, function and neurochemistry. Between the baseline (0 month) and 6-month post-training session, participants will complete visual training at home. Between the 6-month post-training session and 9-month follow up, participants will not complete visual training at home. This study will therefore allow the investigators to determine whether rehabilitation improves conscious visual perception and quality of life as well as providing understanding of the neural mechanisms that underlie this improvement. The investigators will also determine whether improvements or neural changes persist after 3-months without training.
Investigators
DrHollyBridge
Professor
University of Oxford
Eligibility Criteria
Inclusion Criteria
- •Aged 18-80
- •Participant is willing and able to give informed consent for participation in the study
- •Fluent English-speaking healthy adults
- •Has suffered damage to the visual cortex at least 6 months before the study
Exclusion Criteria
- •Previous eye disease or impairment other than hemianopia
- •Neurological or psychiatric illness
- •Contraindication to MRI
- •Pregnant or breast feeding
- •Second stroke during training
- •Data quality assurance (participant data will be removed from analysis for the following reasons):
- •Concurrent participation in other "vision therapy"
- •Unreliable visual fields, indicated by greater than 20% fixation losses, false positives, or false negatives
- •Inability to demonstrate fixation stability on eye movement monitored testing
- •Failure to complete at least 100 training sessions over 6-months
Outcomes
Primary Outcomes
Change in motion discrimination thresholds after 6 months of training
Time Frame: 6 months
Change in normalised discrimination thresholds on psychophysical motion discrimination task at two trained locations between baseline (0-month) and 6-month follow up. These assessments will be based on what motion can be reliably detected at a 75% correct level of performance.
Secondary Outcomes
- Maintenance of improvement in motion discrimination thresholds at 9-month follow up.(9 months)
- Change in visual quality of life(6 months)
- Maintenance of visual quality of life(9 months)
- Maintenance contrast detection at trained locations(9 months)
- Maintenance of white matter integrity(9 months)
- Change in neurochemistry(6 months)
- Change in area improved on the Humphrey perimetry (24-2 and 10-2)(6 months)
- Maintenance area improved on the Humphrey perimetry (24-2 and 10-2)(9 months)
- Change in white matter integrity(6 months)
- Change in brain activity during visual stimulation (Blood-oxygen-level-dependent imaging, or BOLD, signal change)(6 months)
- Change in contrast detection at trained locations(6 months)
- Maintenance of neurochemistry(9 months)
- Maintenance of brain activity during visual stimulation (BOLD signal change)(9 months)
- Change in resting state connectivity(6 months)
- Maintenance of resting state connectivity(9 months)