Intracellular signaling pathways in Peripheral Blood Mononuclear Cells in patients with inflammatory bowel disease.

• Conditions: Crohns disease; ileitis terminalis; inflammatory bowel disease; 10017969

• Registration Number: NL-OMON29966
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 90

Inclusion Criteria

Crohn patients in remission, with (n<=20) and without (n<=20) thiopurine immunesuppression, ulcerative colitis patients in remission (n<=20), rheumatoid arthritis patients on azathioprine (n<=10). Diagnosis made by AMC physisian using standard diagnostic tools. Healthy volunteers recruited among AMC collaborators (n<=20)

Exclusion Criteria

Patients suffering from active disease, patient using immunesuppressive therapy other than azathioprine

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Signal intensity on Western Blots 0, 5, 30 en 60 minutes after stimulation with<br /><br>TNF-alfa or complement factor 5a.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>