The Influence of Infant Feeding Type on Preterm Infant's Intestinal Microbiome
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- CHA University
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- intestinal microbiome composition according to the type of feeding
Study Overview
Brief Summary
This study aims to examine the factors associated with preterm infant's intestinal microbiota depending on feeding type (breast milk or preterm formula)
Detailed Description
The gut microbiome has been increasingly found to affect human health. Feeding plays an important role in determining the composition and diversity of the neonatal gut microbiome. Preterm infants are at a high risk of gut microbiota disruption and dysbiosis because of physiological immaturity and environmental factors. In preterm infants, breast milk has been associated with improved growth and cognitive development and a reduced risk of necrotizing enterocolitis and late onset sepsis.
The objective of study is to determine the impact of feeding type on gut microbiome of very preterm infants admitted in a neonatal intensive care unit (NICU). Meconium and the additional 2 fecal samples will be collected from preterm infants. Fecal samples will be collected every 14 days, during 28 days, from diapers into sterile tubes. DNA will be extracted from fecal samples and different bacterial genus and species will be analyzed.
The type of infant feeding (breast milk or preterm formula) is recorded daily to classify the type of infant feeding received during the 14 days prior to each fecal sample collection.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Very preterm infants (< 32 weeks gestational age) admitted in the NICU of CHA Bundang Medical Center within the first 24 hours after birth
Exclusion Criteria
- •Parents refuse to participate/sign informed consent
- •Major congenital anomalies
Outcomes
Primary Outcomes
intestinal microbiome composition according to the type of feeding
Time Frame: 4 weeks after birth
comparison of intestinal microbiome with 16s RNA gene specific sequencing
Secondary Outcomes
No secondary outcomes reported
Investigators
Hye-Rim Kim
professor
CHA University