Incidence and Patterns of Nausea/Vomiting With Combined Chemotherapy and Radiation

Completed

• Conditions: Cancer of the Lung; Cancer of the Esophagus; Cancer of the Head and Neck; Gastro-esophageal Junction Cancer

• Registration Number: NCT00716157
• Lead Sponsor: Thomas Jefferson University

Brief Summary

Questionnaire study to observe the incidence and pattern or nausea and vomiting in patients receiving combined chemotherapy and radiation. 83% of patients experience radiation therapy-induced vomiting; significant nausea and vomiting could develop with concurrent chemotherapy despite standard anti-nauseous medication prophylaxis.

Detailed Description

Questionnaires will be answered daily on a weekly basis during period of radiation and chemotherapy.

Study Timeline

• Study Start: 2004-10
• Study First Submitted: 2008-07-14
• Study First Submitted QC: 2008-07-15
• Study First Posted: 2008-07-16
• Primary Completion: 2008-08
• Study Completion: 2011-09
• Status Verified: 2014-12
• Last Update Submitted: 2014-12-03
• Last Update Posted: 2014-12-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Concurrent radiation and chemotherapy treatment
• Aerodigestive malignancy

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Exclusion Criteria

• Other causes of vomiting (i.e.gastrointestinal obstruction...)

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assess incidence and patterns of nausea and vomiting in patients undergoing concurrent chemotherapy and radiation	week of treatment

Secondary Outcome Measures

Name	Time	Method
Assess the impact of nausea and vomiting on the patients' daily functioning	week of treatment
Study the incidence of mucositis and esophagitis	week of treatment

Trial Locations

Locations (1)

Thomas Jefferson University; 🇺🇸 Philadelphia, Pennsylvania, United States