Intrauterine Autologous Platelet -Enriched Plasma Infusion Compared to Hormonal Replacement Therapy for Enhancing Endometrial Thickness in Patients Undergoing ICSI
试验速览
- 阶段
- 1 期
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- endometrial thickness in mm
研究概览
简要总结
Successful embryo implantation needs an optimum embryonic development with a receptive endometrium. Endometrial thickness is an independant factor for endometrial receiptivity. The aim of that trial is to assess the benefecial effect of platelt rich plasma in copmarison with standard hormonal therapy.
详细描述
This is a single blinded randomized trial comparing the effect of of platlet rich plasma versus hormonal therapy on endometrial thickness and consequently endometrial receptivity. The primary endpoint of this trial is clinical pregnancy rate.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •patients undergoing ICSI
- •endometrial thickness less than 7 mm on early follicular phase
排除标准
- 未提供
研究组 & 干预措施
Platlet rich plasma
For those with endometrial thickness less than 7 mm intrauterine injection of platlet rich plasma (PRP) for enhancing endometrial thickness and receptivity
干预措施: platlet rich plasma (Biological)
Hormone replacement therapy
Oral intake of estradiol valerate for those with endometrial thickness less than 7 mm will improve endometrial receptivity
结局指标
主要结局
endometrial thickness in mm
时间窗: 72 hours
using transvaginal ultrasound to measure endometrial thickness in mm
次要结局
- clinical pregnancy rate(4 weeks after embryo transfer)
研究者
rasha medhat abdul-hady
DR. Rasha Medhat Abdul-hady
Ain Shams University