Intrauterine Autologous PRP Infusion Compared to HRT for Enhancing Endometrial Thickness in Patients Undergoing ICSI

Phase 1

• Conditions: Infertility

• Registration Number: NCT02660294
• Lead Sponsor: Ain Shams University

Brief Summary

Successful embryo implantation needs an optimum embryonic development with a receptive endometrium. Endometrial thickness is an independant factor for endometrial receiptivity. The aim of that trial is to assess the benefecial effect of platelt rich plasma in copmarison with standard hormonal therapy.

Detailed Description

This is a single blinded randomized trial comparing the effect of of platlet rich plasma versus hormonal therapy on endometrial thickness and consequently endometrial receptivity. The primary endpoint of this trial is clinical pregnancy rate.

Study Timeline

• Study First Submitted: 2016-01-16
• Study First Submitted QC: 2016-01-16
• Study First Posted: 2016-01-21
• Status Verified: 2016-03
• Study Start: 2016-03
• Last Update Submitted: 2016-03-19
• Last Update Posted: 2016-03-22
• Primary Completion: 2017-03
• Study Completion: 2017-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

• patients undergoing ICSI
• endometrial thickness less than 7 mm on early follicular phase

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
endometrial thickness in mm	72 hours	using transvaginal ultrasound to measure endometrial thickness in mm

Secondary Outcome Measures

Name	Time	Method
clinical pregnancy rate	4 weeks after embryo transfer	using transvaginal ultrasound to detect fetal cardiac activity

Trial Locations

Locations (1)

Rasha; 🇪🇬 Cairo, Al Qahirah, Egypt