Vitamin D, HbA1c and Vitamin B12 Levels in Patients

Completed

• Conditions: Serum HbA1c and Vitamin D, Vitamin B12 Values in Periodontal Diseases
• Interventions: Diagnostic Test: HbA1c, Vitamin D, Vitamin B12

• Registration Number: NCT05745779
• Lead Sponsor: Hacettepe University

Brief Summary

Abstract Aim: to compare the serum vitamin D, HbA1c and vitamin B12 levels in patients with gingivitis and four different periodontitis stages diagnosed according to the 2017 Periodontal Disease Classification.

Materials and methods: A total of 606 (378 Female, 228 Male) patients were included in the study. The periodontal status of the patients was diagnosed with gingivitis, stage 1,2,3 and 4 periodontitis groups were formed. HbA1c, vitamin D and vitamin B12 values of the patients were compared and analyzed.

Result:

Conclusion:

Detailed Description

bstract Aim: to compare the serum vitamin D, HbA1c and vitamin B12 levels in patients with gingivitis and four different periodontitis stages diagnosed according to the 2017 Periodontal Disease Classification as determined by the American Academy of Periodontology and the European Federation of Periodontology (AAP-EFP) Materials and methods: A total of 606 (378 Female, 228 Male) patients were included in the study. The periodontal status of the patients was diagnosed with gingivitis, stage 1,2,3 and 4 periodontitis groups were formed. HbA1c, vitamin D and vitamin B12 values of the patients were compared and analyzed.

Study Timeline

• Study Start: 2022-08-11
• Primary Completion: 2022-10-11
• Study Completion: 2022-11-11
• Status Verified: 2023-02
• Study First Submitted: 2023-02-03
• Study First Submitted QC: 2023-02-23
• Last Update Submitted: 2023-02-23
• Study First Posted: 2023-02-27
• Last Update Posted: 2023-02-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 606

Inclusion Criteria

• Patients diagnosed with gingivitis or periodontitis with complete periodontal diagnostic data (Gingival Index(Löe, 1967), Plaque Index(Löe, 1967), Periodontal pocket depths(PD), Clinical Attachment loss (CAL), Radiological data- Interdental Bone loss (IBL) data
• Non-smoker
• Vit D, HbA1c and B12 vit in blood on the date of application to the clinic and/or in the last 3 months. Patients with data on values were included in the study.

Exclusion Criteria

• Patients with missing data and not allowing data use
• Smoker
• The data of pregnant and lactating patients were not included in the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Stage 1 periodontitis	HbA1c, Vitamin D, Vitamin B12	0-15% interdental bone loss
Stage 3 Periodontitis	HbA1c, Vitamin D, Vitamin B12	\>33% interdental bone loss with potential for additional tooth loss
Stage 2 Periodontitis	HbA1c, Vitamin D, Vitamin B12	15-33% interdental bone loss
Gingivitis	HbA1c, Vitamin D, Vitamin B12	0% interdental bone loss
Stage 4 Periodontitis	HbA1c, Vitamin D, Vitamin B12	\>%33 interdental bone loss with potantial for loss of dentition

Primary Outcome Measures

Name	Time	Method
Vitamin B12	t0:baseline	serum Vitamin B12 value
HbA1c	t0:baseline	serum Hemoglobin A1c value
Vitamin D	t0 : baseline	serum Vitamin D value

Trial Locations

Locations (1)

Nigde Omer Halisdemir University, Dentistry Faculty, Periodontology Department; 🇹🇷 Niğde, Turkey