Rubidium-82 Position Emission Computed Tomography (PET) Versus Gated, Rest / Stress Technetium 99-m SPECT

Completed

• Conditions: Myocardial Ischemia; Coronary Artery Disease; Heart Disease
• Interventions: Other: SPECT imaging; Other: PET imaging

• Registration Number: NCT01179230
• Lead Sponsor: Hartford Hospital

Brief Summary

Many stress tests being done today have two parts, the stress test and the pictures of your heart. The investigators are comparing a newer technique to obtain the pictures (PET imaging) to the standard method (SPECT imaging). However, it is not known if the new test is better than the old test. It is important to have a standard to compare these tests to, and that is why people who will be getting a cardiac catheterization are being asked to participate. The information about your arteries from the cardiac catheterization will be used to judge which stress test is better. The investigators hypothesize that the newer method (PET imaging) will be more accurate than the old method (SPECT) in detecting heart disease.

Detailed Description

A SPECT rest image will be obtained using a technetium based isotope. On a separate day, a Rubidium rest PET image will be obtained prior to a Dipyridamole stress test. Subjects will receive both Rubidium and technetium isotopes following the Dipyridamole stress, and will undergo first PET imaging and later SPECT imaging following the stress test. Patients will then go for cardiac catheterization as clinically ordered by their physician.

Study Timeline

• Study Start: 2005-01
• Study First Submitted: 2010-06-08
• Study First Submitted QC: 2010-08-09
• Study First Posted: 2010-08-11
• Status Verified: 2012-07
• Primary Completion: 2012-12
• Study Completion: 2012-12
• Last Update Submitted: 2015-03-19
• Last Update Posted: 2015-03-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 136

Inclusion Criteria

• referred for clinical cardiac catheterization

Exclusion Criteria

• previous CABG
• previous MI
• Asthma or obstructive airway disease
• Intolerance to Dipyridamole
• Moderate to severe valvular disease
• Cardiomyopathy - (ejection fraction less than 45%)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
PET SPECT	SPECT imaging	Subjects will have both types of imaging performed, PET and SPECT
PET SPECT	PET imaging	Subjects will have both types of imaging performed, PET and SPECT

Primary Outcome Measures

Name	Time	Method
Coronary Artery Disease	30 days

Secondary Outcome Measures

Name	Time	Method
Myocardial Ischemia	30 days

Trial Locations

Locations (5)

Hartford Hospital; 🇺🇸 Hartford, Connecticut, United States

Cardiovascular Imaging Technologies, LLC; 🇺🇸 Kansas City, Missouri, United States

Ohio Health Research Institute; 🇺🇸 Columbus, Ohio, United States

The Heart Center, PC; 🇺🇸 Huntsville, Alabama, United States

Sanford Health Clinical Research; 🇺🇸 Fargo, North Dakota, United States