The development of diabetes-associated macrovascular disease in humanized mice
- Conditions
- atherosclerosiscardiovascular disease100110821001265310003216
- Registration Number
- NL-OMON36433
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 128
Patients eligible for participation are diagnosed with T2DM (duration 10-15 yrs) and divided into diabetic patients with CAD or without cardiovascular disease. Patients eligible for participation in the various control groups are patients without a history of T2DM but with CAD, respectively. In addition, healthy individuals who have neither a history of diabetes, cardiovascular disease, inflammatory or autoimmune disease, nor obesity nor any other chronic disease are will be included. Definition of CAD: Coronary artery disease (CAD) CAD is defined as previous myocardial infarction, resting ECG indicative of past MI, positive ECG at exercise stress test, echocardiography stress-test positive for inducible ischemia, evidence of significant coronary artery stenose on angiography with or without typical chest pain. Participants allocated to the different groups will be matched for: - gender - age - smoking - BMI - arterial hypertension - HbA1c (diabetics) - lipid profile
Predefined exclusion criteria for T2DM include diagnosis of T1DM and presence of any of the following (self-reported) medical conditions: - auto-immune diseases - acute or chonic infection - age >80yrs - hemodialysis - immunosuppression - any other unrelated disease. Exclusion criteria for non-diabetics include: - diagnosis of T1DM or T2DM - auto-immune diseases - acute or chonic infection - age >80yrs - hemodialysis - immunosuppression - any other unrelated disease .
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method