MgSO4 Combined With Rocuronium Priming

Not Applicable

• Conditions: Muscle Relaxation
• Interventions: Drug: magnesium sulfate and priming; Drug: priming; Drug: magnesium sulfate

• Registration Number: NCT01389791
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

Priming with either rocuronium or MgSO4 is known to accelerate the effect of rocuronium on muscle relaxation. The purpose of this study is to define the effect of MgSO4 on the rocuronium-priming.

Detailed Description

Acceleration of muscle relaxation is beneficial in rapid-sequence intubation. If MgSO4 combined with priming is efficient in accelerating muscle relaxation, it would be an interesting alternative to rapid-sequence intubation.

Study Timeline

• Study Start: 2011-05
• Study First Submitted: 2011-05-26
• Study First Submitted QC: 2011-07-06
• Study First Posted: 2011-07-08
• Status Verified: 2012-01
• Primary Completion: 2012-01
• Study Completion: 2012-01
• Last Update Submitted: 2012-01-06
• Last Update Posted: 2012-01-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• patients of ASA Ⅰ-Ⅱ
• aged 18~65
• scheduled to undergo elective surgery under general anesthesia

Exclusion Criteria

• risk of pulmonary aspiration
• anticipated airway difficulty
• reactive airway disease
• allergic to study drugs
• neuromuscular / cardiovascular/ renal/ hepatic disease
• atrioventricular conduction disturbance
• BMI < 18.5 or > 24.9
• chronic treatment with calcium channel blocker
• medications which affect muscle relaxation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Mg&priming	magnesium sulfate and priming	Patients in this group receive MgSO4 50mg/kg and 0.06mg/kg of rocuronium before administration of 0.54mg/kg of rocuronium.
priming	priming	patients in this group receive 0.06mg/kg of rocuronium before 0.54mg/kg of rocuronium.
MgSO4	magnesium sulfate	Patients in this group receive intravenous MgSO4 before administration of rocuronium.

Primary Outcome Measures

Name	Time	Method
time from injection of induction dose of rocuronium until 95% depression of TOF	time from injection of induction dose of rocuronium until 95% depression of TOF, upto 5 min

Secondary Outcome Measures

Name	Time	Method
rocuronium duration	time from injection of induction dose of rocuronium until train-of-four count reaches two.	time from injection of induction dose of rocuronium until train-of-four count reaches two.
intubating condition	time from injection of induction dose of rocuronium until tracheal intubation.	rapid sesequence intubation condition is evaluated.

Trial Locations

Locations (1)

Seoul national university Bundang hospital; 🇰🇷 Seongnam, Kyoung-ki-do, Korea, Republic of