A Study to Investigate the Effects of Oxygen in Obesity Hypoventilation Syndrome
Not Applicable
Recruiting
- Conditions
- Obesity Hypoventialtion SyndromeRespiratory - Other respiratory disorders / diseases
- Registration Number
- ACTRN12608000592347
- Lead Sponsor
- Medical Research Institute of New Zealand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
Patients with a new diagnosis of Obesity Hypoventilation Syndrome:
1. Body mass index (BMI) >30kg/m2,
2. Daytime hypercapnia (pCO2 >45mmHg)
Exclusion Criteria
1. Diagnosis of chronic airflow obstruction: post-bronchodilator Forced Expiratory Volume in 1 second (FEV1) to Forced Vital Capacity (FVC) ratio <0.7 and Forced Expiratory Volume in 1 second (FEV1) <80% predicted and > 10 pack year smoking history
2. Patients already receiving treatment with Continuous Positive Airway Pressure (CPAP) or non-invasive positive pressure ventilation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in PaCO2 from baseline measured by a transcutaneous carbon dioxide device attached to the earlobe.[20 minutes]
- Secondary Outcome Measures
Name Time Method Change in minute ventilation measured by gas flow through an electronic pneumotachygraph attached to the mouthpiece of the facemask[20 minutes];Change in dead space to tidal volume ratio. Measured by calculation: a combination of PaCO2 from the transcutaneous carbon dioxide device and mixed expired carbon dioxide measured by an electronic sensor on the mouthpiece of the face mask[20 minutes];A change in PaCO2 from baseline of greater then 4mmHg measured by transcutaneous carbon dioxide device[20 minutes]