The correlation between anthropometry, metabolic profile, laboratory profile, non invasive tests and Fibroscan in MASLD- Metabolic Dysfunction Associated Steatotic Liver Disease: A real world experience

A systemic review and meta‑analysis by Shalimar et al. showed that pooled prevalence was 38.6% in adults and pooled prevalence was 35.4% in children. A systemic review and meta‑analysis by Shalimar et al. showed that pooled prevalence was 38.6% in adults and pooled prevalence was 35.4% in children. A systemic review and meta‑analysis by Shalimar et al. showed that pooled prevalence was 38.6% in adults and pooled prevalence was 35.4% in children. De Silva S, et al, performed a retrospective study on patients with histologically confirmed NAFLD,  showed that blood test-based non-invasive scores are less accurate in South Asian patients, irrespective of metabolic parameters. (population- younger, had lower body mass index) however Transient elastography was equally and highly accurate in both ethnicities. Mathew et al. - retrospective observational analytical study of patients who had a liver biopsy with a diagnosis of NAFLD, in south India- NFS of >0.676 had a sensitivity of 68% and specificity of 100%, and an FIB-4 index of >2.67 had a sensitivity of 67% and specificity of 95.6 % in diagnosing Advance fibrosis. Ornelas et al. -The total accuracy of the Fibroscan was found to be 66% (21 “good” correlation, 11 “poor” correlation). The accuracy of non-alcoholic steatohepatitis (NASH) was 91% compared to 52% for non-NASH liver diseases. Spearman rank correlation between Fibroscan and liver biopsy in NASH patients was found to be both positive and significant (Spearman’s correlation  0.699, P  0.017).