Coherence Between Brain Cortical Function and Neurocognitive Performance During Changed Gravity Conditions
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- alterations in brain cortical activity (EEG)
研究概览
简要总结
Alongside a well-known physiological deconditioning, such as a decrease in muscle mass or bone demineralization, extended stays in weightlessness also cause cognitive dysfunction. However, the studies on this subject during space missions short or long term could not determine how these cognitive dysfunction resulted from a direct effect of weightlessness or a stress-related effect.
Analysis of electro-encephalography (EEG) using a standardized mapping method is used to study the changes of operation of the cerebral cortex as the near infrared spectroscopy (NIRS) is a reflection of changes in the cerebral hemodynamics. Their combined use is a relatively simple and economical method for studying brain changes in an environment where the normal brain imaging techniques can not be used.
The main objective of this experiment is to evaluate the alterations in brain cortical activity and brain oxygenation level induced by micro- and hypergravity conditions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy volunteers (men or women),
- •aged from 18 to 65,
- •affiliated to a Social Security system and, for non-French resident, holding an European Health Insurance Card (EHIC)
- •who accept to take part in the study,
- •who have given their written stated consent,
- •who already participated in parabolic flights (even in the same campaign)
- •All subjects will pass a medical examination similar to a standard aviation medical examination for private pilot aptitude (JAR FCL3 Class 2 medical examination). There will be no additional test performed for subject selection.
排除标准
- •Persons who took part in a previous biomedical research protocol, of which exclusion period is not terminated,
- •Persons with prior serious injuries to their head
- •Persons who take any medication or drugs influencing their central nervous system or cognitive performance
- •Pregnant women.
结局指标
主要结局
alterations in brain cortical activity (EEG)
时间窗: baseline
brain oxygenation level (NIRS)
时间窗: baseline
次要结局
未报告次要终点