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Clinical Trials/NCT06412978
NCT06412978
Recruiting
Not Applicable

Post-Operative Cosmesis and Skin Closure Methods After Cesarean Section

Wake Forest University Health Sciences1 site in 1 country52 target enrollmentStarted: September 5, 2024Last updated:

Overview

Phase
Not Applicable
Status
Recruiting
Enrollment
52
Locations
1
Primary Endpoint
scar cosmetic score

Overview

Brief Summary

Given the high numbers of cesarean deliveries being performed today, there has been interest in optimizing surgical techniques. Several recent reviews have summarized the evidence for various steps of cesarean delivery, but surprisingly in many cases there is little scientific evidence on which to base the choice of surgical technique.

Detailed Description

Cesarean delivery is the most common surgical procedure performed in the United States, with over 1 million procedures performed per year. Based on recent Center for Disease Control (CDC) National Vital Statistics Report (2021) 32.1% of all births in the United States were via cesarean delivery. Given the high numbers of cesarean deliveries being performed today, there has been interest in optimizing surgical techniques. Absorbable staples, made from a combination of polylactic and polyglycolic acid, are a relatively new option for skin closure at the time of surgery. This study is a randomized trial that will investigates two cesarean skin closure techniques-subcuticular, polyglecaprone suture (Monocryl), and absorbable subcuticular polyglycolic acid staples (INSORB)-to determine if one is associated with better scar cosmesis.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Supportive Care
Masking
Single (Outcomes Assessor)

Masking Description

Scars will be digitally photographed by study staff and scored by 2 independent judges. The judges will be blinded to the closure method at time of scar evaluation.

Eligibility Criteria

Ages
18 Years to 44 Years (Adult)
Sex
Female
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Age 18-44
  • Any parity
  • Scheduled cesarean section
  • Neuraxial analgesia

Exclusion Criteria

  • Non-English Speaking
  • Incarcerated
  • Maternal Connective Tissue Disorder
  • Systemic maternal steroid use
  • Three prior cesarean deliveries
  • Body Mass Index (BMI) \>40

Arms & Interventions

subcuticular absorbable polyglycolic acid (INSORB) staples

Active Comparator

Insorb absorbable staples are used for skin closure

Intervention: absorbable subcuticular polyglycolic acid staples (INSORB) (Procedure)

subcuticular absorbable polyglecaprone suture (Monocryl)

Active Comparator

Monocryl absorbable staples are used for skin closure

Intervention: subcuticular, polyglecaprone suture (Monocryl) (Procedure)

Outcomes

Primary Outcomes

scar cosmetic score

Time Frame: Week 6

Scars will be digitally photographed by study staff and scored by 2 independent judges (attending Obstetricians) according to the SCAR scale validated by Kantor with scores ranging from 0 (best) to 15 (worst).

Secondary Outcomes

  • amount of in-hospital oral opiate analgesic use(Week 6)
  • Number of Wound complications(Week 6)
  • length of hospital stay(Week 6)
  • amount of in-hospital oral NSAID analgesic use(Week 6)
  • patient rated subjective pain score(Week 6)
  • patient's overall satisfaction with cosmesis scores(Week 6)
  • amount of in-hospital intravenous opiate analgesic use(Week 6)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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