Ki-67 and cytokeratin 16 expression in several lesion types of hidradenitis suppurativa compared to keratosis pilaris and psoriasis inversa. A pilot investigatio

Recruiting

• Conditions: acne ectopica; acne inversa; hidradenitis suppurativa; 10040798

• Registration Number: NL-OMON43302
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

Healthy controls:
In order to be eligible to participate in this study, a subject must meet all of the following
criteria:
- Subjects are not affected with HS, psoriasis inversa and keratosis pilaris.
- Subjects do not have another skin disease located at the armpits or groins
- Age 18-65 years
*
Patients with psoriasis inversa and keratosis pilaris:
In order to be eligible to participate in this study, a subject must meet all of the following
criteria:
- Subjects are not affected with HS
- Subjects do not have another skin disease located at the site of the affected skin.
- Age 18-65 years;Patients with HS that have pseudo-comedone lesions
In order to be eligible to participate in this study, a subject must meet all of the following
criteria:
- Subjects are not affected with psoriasis inversa. Also, subjects are not affected with keratosis pilaris at the site of pseudo-comedones.
- Subjects do not have another skin disease located at the site of the affected skin.
- Age 18-65 years;Patients with HS with inflammatory nodules via left-over material from STEEP-surgery
- Subjects are not affected with psoriasis inversa. Also, subjects are not affected with keratosis pilaris at the surgical site.
- subjects do not have other skin manifestations at the site of STEEP-surgery, particularly no psoriasis inversa and keratosis pilaris.
- Age 18-65 years

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded from participation
in this study:
- Subjects who have not given informed consent
- Subjects <18 and >65 years old

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To investigate the expression of cytokeratin 16 and ki-67 in the different<br /><br>segments of the FPSU of all the above mentioned conditions</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>N.A. </p><br>