An Exploratory Randomised Controlled Open-Label Study of Methadone Rotation versus Other Opioid Rotation for the Treatment of Refractory Cancer Induced Bone Pain

Dr Merlina Sulistio0 个研究点目标入组 50 人开始时间: 2021年2月11日最近更新: 2021年2月16日

适应症

试验速览

暂无简介。

•Age at least 18 years.
•Diagnosis of solid tumour or haematological cancer with a predicted prognosis of greater than 8 weeks.
•Diagnosis of CIBP confirmed through radiological investigations and meeting the core diagnostic criteria for CIBP as defined by The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks-American Pain Society (ACTTION-APS).
•On a strong baseline opioid pre-rotation (morphine, oxycodone or hydromorphone).
•Willing to be enrolled in a trial comparing methadone to another opioid rotation, where allocation is at random (1:1).
•greater than or equal to 4 of 10 worst pain from CIBP on 0 to 10 numeric rating scale (NRS) and/ or existing opioid results in opioid toxicity (CTCAE grade 2 or greater).
•Sufficiently proficient in English to be able to complete questionnaires and provide informed consent.

•Received radiotherapy in the last 30 days.
•QTc >500msec.
•History of mental health condition or impaired cognition that would prevent completion of questionnaires.
•Too unwell to participate in the study as determined by the patient’s treating physician.

发起方

Dr Merlina Sulistio