PROBEL; Prognostics in the Treatment Evaluation of the National System for Veterans' Care
- Conditions
- Posttraumatische Stressstoornis, Posttraumatic Stress Disorder
- Registration Number
- NL-OMON29049
- Lead Sponsor
- Stichting Centrum '45 partner in ARQ National Psychotrauma Center, Diemen/Oegstgeest, the Netherlands
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 260
Inclusion Criteria
Soldiers and veterans who participated in a military deployment, who meet the diagnostic DSM-5 criteria for PTSD or subthreshold PTSD. Further inclusion criteria are age between 18 and 65 years and having a treatment indication for trauma-focused psychotherapy.
Exclusion Criteria
Acute suicidality and severe psychiatric co-morbidity that would impede undergoing trauma-focused therapy.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome measure is change in PTSD symptom severity during the first year of treatment. We will develop a prognostic model that predicts treatment outcome based on PD (such as, stigma, shame, and guilt), NP (executive functions and verbal memory), and PP (the stress- and immune system) factors collected before starting and after a year of treatment.
- Secondary Outcome Measures
Name Time Method The secondary outcome measures are change during the first year of treatment in depressive symptoms severity and level of daily functioning.