A Phase II Trial of Induction Carboplatin and Docetaxel Followed by Radiotherapy Then Consolidation Chemotherapy With Carboplatin and Docetaxel in Stage III, IV and Recurrent Endometrial Cancer
Overview
- Phase
- Phase 2
- Intervention
- carboplatin
- Conditions
- Endometrial Cancer
- Sponsor
- Masonic Cancer Center, University of Minnesota
- Enrollment
- 41
- Locations
- 2
- Primary Endpoint
- Percent of Patients Estimated to be Progression-Free and Alive
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
RATIONALE: Drugs used in chemotherapy, such as carboplatin and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving combination chemotherapy together with radiation therapy may kill more tumor cells.
PURPOSE: This phase II trial is studying how well giving carboplatin and docetaxel followed by radiation therapy works in treating patients with stage III, stage IV, or recurrent endometrial cancer.
Detailed Description
OBJECTIVES: Primary * Determine the time to progression in patients with stage III or IV or recurrent endometrial cancer treated with induction chemotherapy comprising carboplatin and docetaxel followed by radiotherapy and consolidation chemotherapy comprising carboplatin and docetaxel. Secondary * Determine the toxic effects of this regimen in these patients. * Determine the overall survival of patients treated with this regimen. OUTLINE: Patients receive docetaxel intravenous (IV) over 1 hour and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for 3 courses. After hematologic recovery from chemotherapy, patients receive radiotherapy 5 days a week for up to 7 weeks. Beginning 3-4 weeks later, patients receive another 3 courses of docetaxel and carboplatin. After completion of study treatment, patients are followed periodically for 2 years.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Histologically confirmed endometrial cancer
- •Advanced or recurrent disease
- •Stage IIIB or IIIC disease
- •Stage IIIA disease allowed provided there is serosal involvement or direct extension or metastasis to the adnexa
- •No stage IIIA confirmed by only positive peritoneal washings
- •Stage IVA or IVB disease
- •Failed local therapy or considered incurable with local therapy
- •Measurable or evaluable disease
- •Not required for newly diagnosed stage III or IV disease with no remaining disease after surgery
- •Performance status Gynecology Oncology Group (GOG) 0-1
Exclusion Criteria
- •Known hypersensitivity to docetaxel or polysorbate 80
- •Severe infection
- •Septicemia
- •Pregnant or nursing
- •Positive pregnancy test
- •Fertile patients must use effective nonhormonal contraception during and for at least 3 months after study treatment
- •Peripheral neuropathy ≥ grade 2
- •Severe gastrointestinal bleeding requiring a blood transfusion or hospitalization
- •Other malignancy within the past 5 years except nonmetastatic, nonmelanoma skin cancer or carcinoma in situ of the cervix
- •Prior chemotherapy
Arms & Interventions
Patients with Endometrial Cancer
Patients with advanced or current endometrial cancer receiving treatment with induction docetaxel/carboplatin, radiation (Weekly, 5 days/week over 6-7 weeks, tailored 4500 cGy) and followed by 3 courses of consolidation docetaxel (75 mg/m\^2 on Day 1 of each course) /carboplatin (Dose = Area-under-the-curve 6 on Day 1 every 3 weeks for 3 cycles).
Intervention: carboplatin
Patients with Endometrial Cancer
Patients with advanced or current endometrial cancer receiving treatment with induction docetaxel/carboplatin, radiation (Weekly, 5 days/week over 6-7 weeks, tailored 4500 cGy) and followed by 3 courses of consolidation docetaxel (75 mg/m\^2 on Day 1 of each course) /carboplatin (Dose = Area-under-the-curve 6 on Day 1 every 3 weeks for 3 cycles).
Intervention: docetaxel
Patients with Endometrial Cancer
Patients with advanced or current endometrial cancer receiving treatment with induction docetaxel/carboplatin, radiation (Weekly, 5 days/week over 6-7 weeks, tailored 4500 cGy) and followed by 3 courses of consolidation docetaxel (75 mg/m\^2 on Day 1 of each course) /carboplatin (Dose = Area-under-the-curve 6 on Day 1 every 3 weeks for 3 cycles).
Intervention: radiation therapy
Outcomes
Primary Outcomes
Percent of Patients Estimated to be Progression-Free and Alive
Time Frame: 1 Year, 2 Years, 3 Years
This estimate was determined by using a statistical method of analysis (Kaplan-Meier).
Secondary Outcomes
- Percent of Patients Estimated to be Alive(1 Year, 2 Years, 3 Years)