The effect of inhibition of a transporter on sedation after antihistamine administration.
Completed
- Conditions
- Healthy subjects, sedation, antihistamines, P-glycoproteintransporter, fMRI, attention.Gezonde proefpersonen, vermoeidheid, antihistamines, P-glycoproteinetransporter, fMRI, aandacht.
- Registration Number
- NL-OMON26369
- Lead Sponsor
- Maastricht University
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 16
Inclusion Criteria
1. Aged between 18 and 45 years;
2. Healthy volunteers;
Exclusion Criteria
1. Medical history of major medical, psychiatric illness or surgery which, in the judgement of the investigator, could jeopardize their health or is likely to modify their handling of the study drug;
2. Any non corrected visual defect or locomotor disorder which could interfere with the study;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The mean reaction time (ms) of the Attention Network Test (ANT).
- Secondary Outcome Measures
Name Time Method Cognitive tests:<br /><br>1. The attention network test;<br /><br>2. The simple reaction time test;<br /><br>3. MRI resting state;<br /><br>4. The BOLD signal.