The Timing of Cognitive Impairments in Psychotic Disorders
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Psychotic Disorders
- Sponsor
- Sheba Medical Center
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Changes in DAPAR (An Israeli cognitive test) scores
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
Patients with Psychotic disorders (Schizophrenia, Bipolar disorder and Schizoaffective disorder) often suffer from significant cognitive impairments, however how these develop and change over time before and after the first psychotic break is unclear. While there are data by several groups, showing that many future patients have significant cognitive impairments years before the onset of psychosis, many future patients seem to be doing well before the manifestation of psychosis, and decline steeply in functioning after their first psychotic episode. Hence the timing of the onset of cognitive impairment in patients with psychotic disorders requires further exploration. The current study will investigate the timing of cognitive impairment by using IQ tests before and after the first psychotic break
Detailed Description
In this study the investigators aim to use the DAPAR tests (A cognitive assessment which all 17 year old Jewish adolescents in Israel undergo to participate in mandatory military service), which measures intelligence, and is equivalent to the IQ test. The subjects will be persons who had their first psychotic break, at least one year following the DAPAR tests. As part of the study, the participants will re-take the DAPAR tests, after the onset of the psychotic illness.
Investigators
Mark Weiser, MD, Principal Investigator
Head of Psychiatry
Sheba Medical Center
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Changes in DAPAR (An Israeli cognitive test) scores
Time Frame: 1 day (During recruitment visit)
Cognitive changes in both groups (lowest 10 - highest 90)
Secondary Outcomes
- Social Functioning(1 day (During recruitment visit))
- Psychotic Symptoms(1 day (During recruitment visit))
- Coping strategies(1 day (During recruitment visit))
- Cognitive Functioning(1 day (During recruitment visit))