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临床试验/NCT05597579
NCT05597579招募中不适用

The Timing of Cognitive Impairments in Psychotic Disorders

Sheba Medical Center1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2020年2月12日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
200
试验地点
1
主要终点
Changes in DAPAR (An Israeli cognitive test) scores

研究概览

简要总结

Patients with Psychotic disorders (Schizophrenia, Bipolar disorder and Schizoaffective disorder) often suffer from significant cognitive impairments, however how these develop and change over time before and after the first psychotic break is unclear. While there are data by several groups, showing that many future patients have significant cognitive impairments years before the onset of psychosis, many future patients seem to be doing well before the manifestation of psychosis, and decline steeply in functioning after their first psychotic episode. Hence the timing of the onset of cognitive impairment in patients with psychotic disorders requires further exploration. The current study will investigate the timing of cognitive impairment by using IQ tests before and after the first psychotic break

详细描述

In this study the investigators aim to use the DAPAR tests (A cognitive assessment which all 17 year old Jewish adolescents in Israel undergo to participate in mandatory military service), which measures intelligence, and is equivalent to the IQ test. The subjects will be persons who had their first psychotic break, at least one year following the DAPAR tests. As part of the study, the participants will re-take the DAPAR tests, after the onset of the psychotic illness.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 30 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • 未提供

排除标准

  • 未提供

结局指标

主要结局

Changes in DAPAR (An Israeli cognitive test) scores

时间窗: 1 day (During recruitment visit)

Cognitive changes in both groups (lowest 10 - highest 90)

次要结局

  • Social Functioning(1 day (During recruitment visit))
  • Psychotic Symptoms(1 day (During recruitment visit))
  • Coping strategies(1 day (During recruitment visit))
  • Cognitive Functioning(1 day (During recruitment visit))

研究者

申办方类型
Other Gov
责任方
Principal Investigator
主要研究者

Mark Weiser, MD, Principal Investigator

Head of Psychiatry

Sheba Medical Center

研究点 (1)

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