reGional Network for Acute Myocardial Infarction

Not Applicable

• Conditions: Coronary Heart Disease; STEMI - ST Elevation Myocardial Infarction; Acute Myocardial Infarction
• Interventions: Behavioral: public education and network construction

• Registration Number: NCT03928119
• Lead Sponsor: Guangdong Provincial People's Hospital

Brief Summary

Incidence of ST-segment Elevation Myocardial Infarction (STEMI) is rising and the existing emergency medical aid system for STEMI was not enough for timely perfusion treatment. No existing research with high-quality data focuses on the characteristic of STEMI incidence and regional network construction. Aiming of Guangdong GAMI(reGional network for Acute Myocardial Infarction) project is to establish effective collaborative regional network system for STEMI patients treatment.

Detailed Description

The project of Guangdong GAMI(reGional network for Acute Myocardial Infarction) is being conducted during 2015-2019 in eight districts with diverse economic development across southern China (Integrated care model was conducted in four regions, which mainly included community public education, non primary-PCI capable centre and referral system improvement, and inhospital green-channal optimization for primary-PCI capable centre. Other four centers were underwent usual care of acute myocardial infacrtion public and medical health service). All the ST-segment elevation myocardial infarction (STEMI) patients admitted in the hospital within 30 days from the symptom onset were enrolled. The key data of the timeline of STEMI onset and treatment were precisely recorded. Other details of STEMI treatment in hospitals such as laboratory data and medication were also collected. During the research period, actions of both optimizing the regional STEMI patients transfer and treatment to shorten the medical delay, as well as educating the public to improve their awareness of early treatment of STEMI were taken meanwhile. In addition, laboratory data, medication, and follow-up information were recorded in a database for further analysis regarding the STEMI patient treatment.

Study Timeline

• Study Start: 2015-08-01
• Study First Submitted: 2019-04-21
• Study First Submitted QC: 2019-04-23
• Study First Posted: 2019-04-25
• Primary Completion: 2020-02-28
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-26
• Last Update Posted: 2022-06-01
• Study Completion: 2024-02-28

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 7102

Inclusion Criteria

All adult patients who suspected diagnosis with STEMI.

Exclusion Criteria

1. patients refused to undergo coronary angiography;
2. patients were confirmed as non-STEMI by coronary angiography or the course of STEMI over 1 month;
3. patients occurred onset STEMI during hospitalization in hospitals

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
Intervention group	public education and network construction	community public education, non-PCI center and emergency transfer system improvement, and inhospital green-channal optimization for PCI center.

Primary Outcome Measures

Name	Time	Method
Receipt of reperfusion therapy within 12 hoursInfarction patients	From 1 month before hospitalization to 24 hours after hospitalization	The primary outcome was the proportion of patients who received symptom-to-reperfusion treatment within 12 hours.

Secondary Outcome Measures

Name	Time	Method
In-hospital clinical outcomes	30 days	The incidence of several in-hospital outcomes (in-hospital death; and major adverse cardiac events \[MACEs\], which mainly included in-hospital death, recurrence of myocardial infarction, and stroke); the length of stay.
1-year all-cause mortality	1 year	Total mortality between 30 days and 1 year after discharge.
Onset-to-admission time within 12 hours	From 1 month before hospitalization to 24 hours after hospitalization	The proportion of patients who take a symptom-to-admission period within 12 hours.
Door-to-balloon time within 90 minutes	24 hours	The proportion of patients who take a door-to-balloon period within 90 minutes.

Trial Locations

Locations (8)

Longyan First Hospital Affiliated to Fujian Medical University; 🇨🇳 Longyan, Fujian, China

Dongguan People's Hospital; 🇨🇳 Dongguan, Guangdong, China

Shunde Hospital of Southern Medical University; 🇨🇳 Foshan, Guangdong, China

Maoming People's Hospital; 🇨🇳 Maoming, Guangdong, China

Guangdong Provincial People's Hospital; 🇨🇳 Guangzhou, Guangdong, China

Guangzhou Panyu Central Hospital; 🇨🇳 Guangzhou, Guangdong, China

People's Hospital of Yangjiang; 🇨🇳 Yangjiang, Guangdong, China

Shenzhen People's Hospital; 🇨🇳 Shenzhen, Guangdong, China