Comparative Study of Different Bone Grafts in Accelerating Tooth Movement

Not Applicable

Completed

• Conditions: Orthodontics
• Interventions: Drug: Xenograft; Drug: Bioactive glass

• Registration Number: NCT02796911
• Lead Sponsor: King Abdulaziz University

Brief Summary

Objective: Periodontally accelerated osteogenic orthodontics(PAOO) will minimize treatment time. The current study will be carried to evaluate the effectiveness of different bone grafts with a modified, less invasive corticotomy technique in the treatment of adult patients with moderate crowding.

Subjects and Methods: Thirty orthodontic patients will be selected. Patients were randomly classified into three groups. Group I will be treated with a modified technique of corticotomy, whereas group II will be treated with the same technique combined with PAOO using bovine derived xenograft, and group III will be treated with the same technique combined with PAOO using with bioactive glass. The total duration of active orthodontic treatment will be estimated. Probing depth, bone density and root length will be also evaluated. The measurements will be recorded.

Detailed Description

Objective: Periodontally accelerated osteogenic orthodontics(PAOO) combines periodontal therapy with orthodontic therapy, which will minimize treatment time. The current study will be carried to evaluate the effectiveness of bovine derived xenograft versus bioactive glass with a modified, less invasive corticotomy technique in the treatment of adult patients with moderate crowding.

Subjects and Methods: Thirty orthodontic patients will be selected. Patients were randomly classified into three groups. Group I will be treated with a modified technique of corticotomy on the labial side only, whereas group II will be treated with the same technique combined with PAOO using bovine derived xenograft, and group III will be treated with the same technique combined with PAOO using with bioactive glass. The total duration of active orthodontic treatment will be estimated from the time of starting the active orthodontic treatment, immediately following the corticotomy procedure, to the time of debonding. Probing depth will be evaluated clinically whereas bone density and root length will be evaluated radiographically. The measurements will be recorded at day of surgery (baseline) (T1), post-treatment at time of debonding (T2), and 9 months post-treatment (T3).

Study Timeline

• Study Start: 2015-09-01
• Study First Submitted: 2016-06-07
• Study First Submitted QC: 2016-06-07
• Study First Posted: 2016-06-13
• Primary Completion: 2016-07-01
• Study Completion: 2016-07-01
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-29
• Last Update Posted: 2024-04-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• A moderate 4-5mm crowding of the lower anterior teeth
• Good oral hygiene
• Healthy systemic condition

Exclusion Criteria

• previous orthodontic treatment
• Probing depth values exceeding 3 mm
• Radiographic evidence of bone loss
• Regular administration medication that affects bone metabolism such as prolonged use of corticosteroids, or bisphosphonates and NSAIDs.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Corticotomy + xenograft	Xenograft	group II (included 6 females and 5 males) that treated with CAOT combined with bovine derived xenograft (Biogen, Biotecksrl Fermi, Arcugraro VI, Italy);
Corticotomy + bioactive glass	Bioactive glass	group III (included 7 females and 4 males) that treated with CAOT combined with bioactive glass (Bio-Glass, Excellence Pharm Inc., Egypt).

Primary Outcome Measures

Name	Time	Method
Speed of tooth movement	Baseline (T1), post-treatment at time of debonding (T2), and 9 months post-treatment (T3).	The total duration of active orthodontic treatment will be estimated in weeks from the time of starting the active orthodontic treatment, immediately following the corticotomy procedure, to the time of debonding.

Secondary Outcome Measures

Name	Time	Method
Bone density	Baseline (T1), post-treatment at time of debonding (T2), and 9 months post-treatment (T3).	Bone density will be evaluated radiographically
Root length	Baseline (T1), post-treatment at time of debonding (T2), and 9 months post-treatment (T3).	Root length will be evaluated radiographically

Trial Locations

Locations (1)

King Abdelaziz University. Faculty of dentistry; 🇸🇦 Jeddah, Saudi Arabia