Comparison of Propofol- Nalbuphine and Propofol- Fentanyl induction combinations in Total Intravenous Anaesthesia.

Peoples College of Medical Sciences RC0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•Total 100 adult patients between age group of 30 to 65 years belonging to ASA I and II of either sex under- going surgical procedures up to 90 min duration will be included in the study.The patients will be divided into two groups of 50 patients each. Patients taken for procedure at odd serial no. 1,3,5... of 100 patients (Group 1) will receive Nalbuphine 0.2mg/Kg body weight IV and patients taken for surgery at even serial no. 2,4,6 of 100 patients ..(Group 2) will receive Inj. Fentanyl 2Î¼g/Kg body weight IV 5 min before induction.Maintenance of Anaesthesia will be done with infusion of I/V Propofol 10 mg/kg/hour for 10 min, 08mg/kg/hour for next 10 min and 06 mg/Kg/hour for remaining duration. Supplemental dose of 25 mg of Propofol will be given during surgical procedure if required. Inj. Vecuronium 0.015 mg/Kg Body weight will be given every 20 to 40 min. All the patients will be ventilated with O2 and N2O with controlled ventilation and breathing circuit attached to circle absorber.At the end of surgerical procedure residual neuro-muscular paralysis will be reversed with Inj. Neostigmine 0.05mg/kg body Wt. and Inj. Glycopyrolate 0.008mg/kg body Wt. intravenously. Sedation characteristics will be noted. The patients will be observed in post operative period for any symptom and sign. The vital parameters will also be observed.

•The patients with previous history of hypersensitivity to any of study drug, allergy to egg or fat, on long term Phenothiazines and MAO Inhibitors, anticipated difficult intubation, patients with significant systemic diseases like cardiovascular, renal, hepatic diseases, H/O Bronchial asthma and other respiratory diseases, Alcohol abuse, H/O seizure disorders, thyroid disease, neurological disorders, H/O opium addiction, recent H/O head injury, pregnant women , patients of ASA III and above and patients who will not give consent will also be excluded

发起方

Peoples College of Medical Sciences RC