Prevalence of Chronic Rhinosinusitis, Pathogen-colonization in the Upper and Lower Airways and Ability to Smell in Cystic Fibrosis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Dynamics in CF upper and lower airway colonization with pathogens
研究概览
简要总结
Aim of the study is to detect the prevalence of chronic rhinosinusitis, pathogen colonization of the lower and upper airways and, in a sub-cohort the sense of smelling in patients with cystic fibrosis.
详细描述
The sub-study on the sense of smelling in CF has been finalized in the meantime. Results were published in 2012:
Smell in cystic fibrosis. Lindig J, Steger C, Beiersdorf N, Michl R, Beck JF, Hummel T, Mainz JG. Eur Arch Otorhinolaryngol. 2013 Mar;270(3):915-21. doi: 10.1007/s00405-012-2124-2. Epub 2012 Aug 14.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subject has a confirmed diagnosis of cystic fibrosis
排除标准
- 未提供
结局指标
主要结局
Dynamics in CF upper and lower airway colonization with pathogens
时间窗: 10 years
longitudinal non-invasive sampling of upper and lower airways in CF
Assessment of ability to smell in CF patients
时间窗: 3 years
次要结局
- pulmonary function / BMI(10 years)
研究者
PD Dr. Jochen G. Mainz
Head of CF Center, Pediatric Pulmonology
University of Jena