Efficacy Study of Cognitive Intervention in Amnestic Mild Cognitive Impairment
- Conditions
- Mild Cognitive Impairment
- Registration Number
- NCT01358955
- Lead Sponsor
- Inha University Hospital
- Brief Summary
* There will be a significant difference in cognitive function between cognitive intervention group (group therapy) and a wait list control group.
* There will be a significant difference in cognitive function between a home-based cognitive intervention group and a wait list control group.
- Detailed Description
The change of Modified ADAS-cog score from the baseline to post-intervention will be compared between the cognitive intervention group and wait list control group.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 293
- 50 to 85 years of age
- memory complaint corroborated by a participant and an informant
- delayed recall score on the Seoul Verbal Learning Test (SVLT) below 1.0 standard deviations from the mean of the age and education-normative values among the Korean population
- Global CDR score is 0.5, Memory CDR score is 0.5 or 1.
- above 1.5 standard deviations from the mean of normative data of the respective age- and education-matched population on the Korean Mini-Mental State Examination
- normal functional activities
- not diagnosed with dementia
- Modified Hachinski Ischemic Score (HIS): 0-4
- brain magnetic resonance imaging or CT showing no clinical evidence of other diseases (i.e., normal pressure hydrocephalus, brain tumor, cerebrovascular disease) capable of producing cognitive impairment.
- Subjects are also required to have a reliable caregiver who meet the patient at least once a week and is sufficiently familiar with the patient to provide the investigator with accurate information.
- He/She can read and write
- written informed consent
- any patient who were involved in other clinical trials or treated with experimental drug within 4 weeks
- any patients with any severe or unstable medical disease that may prevent the patient from completing all study requirements (i.e., unstable or severe asthma or cardiovascular disease, active gastric ulcer, severe hepatic or renal disease)
- any patients with clinically significant laboratory abnormalities such as an abnormal thyroid function test, abnormal low level of vitamin B12 or folate, or positive venereal disease research laboratory test
- any patients with any primary neurodegenerative disorder or psychiatric disorder other than AD (i.e., Parkinson's disease, schizophrenia, or major depressive disorder)
- any patients with any history of drug or alcohol addiction during the past 10 years
- any hearing or visual impairment that can disturb the efficient evaluation of the patient
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Modified Alzheimer's Disease Assessment Scale-Cognitive subscale(ADAS-cog) postintervention, 12 weeks follow-up, and 24 weeks follow-up
- Secondary Outcome Measures
Name Time Method story recall test postintervention, 12 weeks follow-up, and 24 weeks follow-up Digit span forward and backward postintervention, 12 weeks follow-up, and 24 weeks follow-up Word fluency test postintervention, 12 weeks follow-up, and 24 weeks follow-up color-word stroop test postintervention, 12 weeks follow-up, and 24 weeks follow-up Digit symbol test postintervention, 12 weeks follow-up, and 24 weeks follow-up prospective memory test postintervention, 12 weeks follow-up, and 24 weeks follow-up Mini-Mental State Examination postintervention, 12 weeks follow-up, and 24 weeks follow-up CDR-SB postintervention, 12 weeks follow-up, and 24 weeks follow-up K-AD8 postintervention, 12 weeks follow-up, and 24 weeks follow-up PRMQ postintervention, 12 weeks follow-up, and 24 weeks follow-up MMQ-Strategy postintervention, 12 weeks follow-up, and 24 weeks follow-up QOL-AD postintervention, 12 weeks follow-up, and 24 weeks follow-up Geriatric Depression Scale-short form postintervention, 12 weeks follow-up, and 24 weeks follow-up Bayer ADL postintervention, 12 weeks follow-up, and 24 weeks follow-up CGA-NPI postintervention, 12 weeks follow-up, and 24 weeks follow-up Subjective cognitive assessment postintervention, 12 weeks follow-up, and 24 weeks follow-up
Trial Locations
- Locations (18)
Korea University Medical College
🇰🇷Ansan, Korea, Republic of
Soonchunhyang University Hospital
🇰🇷Bucheon, Korea, Republic of
Bucheon St. Mary's Hospital, the Catholic University of Korea
🇰🇷Bucheon, Korea, Republic of
Donga University Hospital
🇰🇷Busan, Korea, Republic of
Pusan National University Hospital
🇰🇷Busan, Korea, Republic of
Daejun Eulji University Hopistal
🇰🇷Daejun, Korea, Republic of
Myongji Hospital
🇰🇷Goyang, Korea, Republic of
NHIC Ilsan Hospital
🇰🇷Goyang, Korea, Republic of
Inha Univeristy Hospital
🇰🇷Incheon, Korea, Republic of
Jeju National University Hospital
🇰🇷Jeju, Korea, Republic of
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