In trauma patients with moderate to severe pain, will treatment with low dose Ketamine as an analgesic adjunct with opiates compared to conventional treatment of opiate only improve pain outcomes?

The Townsville Hospital0 个研究点目标入组 100 人开始时间: 2015年9月18日最近更新: 2020年1月13日

适应症

试验速览

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•all patients eligible will have to have presented to the emergency department
•- Age greater than or equal to18years
•- Major traumatic injuries that in the opinion of the treating emergency physician are likely to require high doses of opioid analgesia
•- Have received at least one initial dose of morphine (0.1mg/kg), or morphine-equivalent opiate dosing (e.g. 10mcg/kg fentanyl), with ongoing pain scores of greater than or equal to 60mm

•Known allergy to ketamine or morphine
•- Any state (e.g. intoxication) or medical history (e.g. mental health disorder) impairing accurate pain assessment or ability to provide informed consent
•- Inability to communicate a pain score/complete follow-up questionnaire (intubation, sedation, altered level of consciousness, major head injury, significant anterograde amnesia, dementia, delirium, significant illness, poor English)
•- Administration of ketamine prior to arrival in ED
•- Administration of ketamine in the ED prior to patient recruitment (e.g. analgesia, procedural sedation)
•- Clinical conditions in which the treating clinician is concerned that small increases in intracranial pressure may be deleterious
•- Known or suspected raised intraocular pressure
•- Current major psychiatric episode such as acute psychosis, mania or severe depression
•- Pregnancy or breast feeding
•- Known/suspected drug dependence

发起方

The Townsville Hospital