Supplementing Pain management in the emergency department – Conventional treatment versus Intravenous Adjunctive Low dose Ketamine: A single blind randomised control trial of ketamine versus opioids for trauma patients with moderate to severe pai

Phase 4

• Conditions: Pain in trauma patients; Injuries and Accidents - Other injuries and accidents; Anaesthesiology - Pain management

• Registration Number: ACTRN12615000978561
• Lead Sponsor: The Townsville Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-09-18
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

all patients eligible will have to have presented to the emergency department
- Age greater than or equal to18years
- Major traumatic injuries that in the opinion of the treating emergency physician are likely to require high doses of opioid analgesia
- Have received at least one initial dose of morphine (0.1mg/kg), or morphine-equivalent opiate dosing (e.g. 10mcg/kg fentanyl), with ongoing pain scores of greater than or equal to 60mm

Exclusion Criteria

Known allergy to ketamine or morphine
- Any state (e.g. intoxication) or medical history (e.g. mental health disorder) impairing accurate pain assessment or ability to provide informed consent
- Inability to communicate a pain score/complete follow-up questionnaire (intubation, sedation, altered level of consciousness, major head injury, significant anterograde amnesia, dementia, delirium, significant illness, poor English)
- Administration of ketamine prior to arrival in ED
- Administration of ketamine in the ED prior to patient recruitment (e.g. analgesia, procedural sedation)
- Clinical conditions in which the treating clinician is concerned that small increases in intracranial pressure may be deleterious
- Known or suspected raised intraocular pressure
- Current major psychiatric episode such as acute psychosis, mania or severe depression
- Pregnancy or breast feeding
- Known/suspected drug dependence

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
pain scores: Visual analogue scale will be used to subjectively measure the participants pain. [60 minutes post trial initial administration of IV ketamine or opiate];Analgesia requirements (total doses of adjunct and opiate medications). <br>A review of patient records in retrospective will provide the information of breakthrough analgesia required by all participants.[review of analgesia requirement from initial dose of either control or intervention medications through to 72 hours post initial dose.]